Guduchi

Last Updated: September 28 2022

Tinospora cordifolia, also known as Guduchi or Amrita, is an immune system boosting herb that can potently reduce the symptoms of allergic rhinitis. It is a promising anti-cancer herb and may provide benefits for people with diabetes.

Guduchi is most often used for

Summary

Tinospora cordifolia is an herb used in Ayurveda to enhance vitality. It is being researched for a variety of health effects, including its effect on diabetes, glucose metabolism, inflammation, immune system support, and neurology.

Tinospora cordifolia supplementation improves the ability of macrophages, an immune system cell, to consume their targets, though this effect is not immunostimulatory. Supplementation can also ward off allergies. One study suggests Tinospora cordifolia is as potent as Spirulina as an anti-allergic supplement.

Preliminary evidence suggests Tinospora cordifolia may provide benefits for people with diabetes. Supplementation of Tinospora cordifolia can reduce the body’s absorption of sugar-derived carbohydrates, and it may also play a role in reducing the pathologies associated with diabetes, like retinopathy and nephropathy. There is currently no human evidence for these effects.

Tinospora cordifolia may be a monoamine oxidase (MAO) inhibitor, which means it may raise catecholamine levels. The plant may also contain phytoandrogen, which means it can protect against DNA damage induced by the environment and radiation therapy. Finally, Tinospora cordifolia may have Adaptogen-like properties.

What else is Guduchi known as?
Note that Guduchi is also known as:
  • Guduchi
  • Makabuhay
  • Amrita
  • Giloya
  • Giloe
  • Tinospora Cordifolia
Dosage information

To supplement Tinospora cordifolia, take 1g of a 5% bitters water extract of the stem. The standard dose is 300mg, taken three times a day.

To supplement Amrita Ghrita (Tinospora cordifolia with ghee and ginger), take 10 – 15 g, once a day. This is the traditional Ayurveda dosage.

Tinospora cordifolia should be taken with a meal.

Join our supplement information course

Enter your email to get a FREE five-day course on supplements. 100% backed by science, we take an independent and unbiased approach to figure out what works (and what's a waste of time and money).

    The only 100% independent company. While everyone sells supplements, we only analyze research.

    Examine Database
    Evidence + Benefits at a glance

    Easily compare what works and what doesn't.

    Learn More

    Don't miss out on the latest research

    Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more

      References
      3.^Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PFEfficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trialJ Pharmacol Pharmacother.(2013 Jan)
      4.^Chougale AD, Ghadyale VA, Panaskar SN, Arvindekar AUAlpha glucosidase inhibition by stem extract of Tinospora cordifoliaJ Enzyme Inhib Med Chem.(2009 Aug)
      5.^Badar VA, Thawani VR, Wakode PT, Shrivastava MP, Gharpure KJ, Hingorani LL, Khiyani RMEfficacy of Tinospora cordifolia in allergic rhinitisJ Ethnopharmacol.(2005 Jan 15)
      6.^Vaghamshi R, Jaiswal M, Patgiri BJ, Prajapati PK, Ravishankar B, Shukla VJA comparative pharmacological evaluation of Taila (oil) and Ghrita (ghee) prepared with Guduchi (Tinospora cordifolia)Ayu.(2010 Oct)
      7.^Saha S, Ghosh STinospora cordifolia: One plant, many rolesAnc Sci Life.(2012 Apr)
      8.^Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao SImmunomodulatory active compounds from Tinospora cordifoliaJ Ethnopharmacol.(2012 Jun 14)
      10.^Chandrasekaran CV, Mathuram LN, Daivasigamani P, Bhatnagar UTinospora cordifolia, a safety evaluationToxicol In Vitro.(2009 Oct)
      12.^Srinivasan GV, Unnikrishnan KP, Rema Shree AB, Balachandran IHPLC Estimation of berberine in Tinospora cordifolia and Tinospora sinensisIndian J Pharm Sci.(2008 Jan)
      13.^Sharma U, Bala M, Saini R, Verma PK, Kumar N, Singh B, Munshi RK, Bhalerao SPolysaccharide enriched immunomodulatory fractions from Tinospora cordifolia (Willd) miers ax hook. f. & ThomsIndian J Exp Biol.(2012 Sep)
      14.^Sarma DN, Khosa RL, Sahai MIsolation of jatrorrhizine from Tinospora cordifolia rootsPlanta Med.(1995 Feb)
      20.^Sivasubramanian A, Gadepalli Narasimha KK, Rathnasamy R, Campos AMA new antifeedant clerodane diterpenoid from Tinospora cordifoliaNat Prod Res.(2012 Sep 4)
      21.^Kapil A, Sharma SImmunopotentiating compounds from Tinospora cordifoliaJ Ethnopharmacol.(1997 Oct)
      23.^Pan L, Terrazas C, Lezama-Davila CM, Rege N, Gallucci JC, Satoskar AR, Kinghorn ADCordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifoliaOrg Lett.(2012 Apr 20)
      24.^Swaminathan K, Sinha UC, Bhatt RK, Sabata BK, Tavale SSStructure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia MiersActa Crystallogr C.(1989 Jan 15)
      25.^Alam P, Ali M, Singh R; Madhurima, Ahmad S, Shakeel FA validated HPLC method for estimation of cordifolioside A in Tinospora cordifolia, Miers and marketed formulationsJ Chromatogr Sci.(2009 Nov-Dec)
      26.^Gangan VD, Pradhan P, Sipahimalani AT, Banerji ACordifolisides A, B, C: norditerpene furan glycosides from Tinospora cordifoliaPhytochemistry.(1994 Oct)
      27.^Ahmad F, Ali M, Alam PNew phytoconstituents from the stem bark of Tinospora cordifolia MiersNat Prod Res.(2010 Jun)
      34.^Koppada R, Norozian FM, Torbati D, Kalomiris S, Ramachandran C, Totapally BRPhysiological effects of a novel immune stimulator drug, (1,4)-α-D-glucan, in ratsBasic Clin Pharmacol Toxicol.(2009 Oct)
      50.^Kalekar SA, Munshi RP, Bhalerao SS, Thatte UMInsulin sensitizing effect of 3 Indian medicinal plants: an in vitro studyIndian J Pharmacol.(2013 Jan-Feb)
      52.^Nadig PD, Revankar RR, Dethe SM, Narayanswamy SB, Aliyar MAEffect of Tinospora cordifolia on experimental diabetic neuropathyIndian J Pharmacol.(2012 Sep-Oct)
      54.^Patel MB, Mishra SHypoglycemic activity of alkaloidal fraction of Tinospora cordifoliaPhytomedicine.(2011 Sep 15)
      58.^Stanely Mainzen Prince P, Menon VPAntioxidant action of Tinospora cordifolia root extract in alloxan diabetic ratsPhytother Res.(2001 May)
      60.^Prince PS, Kamalakkannan N, Menon VPRestoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar ratsActa Pol Pharm.(2004 Jul-Aug)
      61.^Rathi SS, Grover JK, Vikrant V, Biswas NRPrevention of experimental diabetic cataract by Indian Ayurvedic plant extractsPhytother Res.(2002 Dec)
      62.^Gustavsson C, Agardh E, Bengtsson B, Agardh CDTNF-alpha is an independent serum marker for proliferative retinopathy in type 1 diabetic patientsJ Diabetes Complications.(2008 Sep-Oct)
      64.^Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GLCharacterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growthJ Clin Invest.(1996 Nov 1)
      66.^Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar GJ, Sainis KBMolecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifoliaImmunol Lett.(2009 Mar 24)
      68.^Nair PK, Melnick SJ, Ramachandran R, Escalon E, Ramachandran CMechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifoliaInt Immunopharmacol.(2006 Dec 5)
      71.^Check J, Byrd CL, Menio J, Rippe RA, Hines IN, Wheeler MDSrc kinase participates in LPS-induced activation of NADPH oxidaseMol Immunol.(2010 Jan)
      74.^Bapat RD, Rege NN, Koti RS, Desai NK, Dahanukar SACan we do away with PTBDHPB Surg.(1995)
      77.^Vanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M, Willems FTumoricidal activity of monocyte-derived dendritic cells: evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanismJ Immunol.(2001 Oct 1)
      79.^Rechnagel RO, Glende EA JrCarbon tetrachloride hepatotoxicity: an example of lethal cleavageCRC Crit Rev Toxicol.(1973 Nov)
      82.^Thatte UM, Rao SG, Dahanukar SATinospora cordifolia induces colony stimulating activity in serumJ Postgrad Med.(1994 Oct-Dec)
      83.^Kalikar MV, Thawani VR, Varadpande UK, Sontakke SD, Singh RP, Khiyani RKImmunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patientsIndian J Pharmacol.(2008 Jun)
      84.^Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M, Huszar M, White MR, Dinarello CA, Apte RNThe role of macrophage-derived IL-1 in induction and maintenance of angiogenesisJ Immunol.(2009 Oct 1)
      85.^Piemonti L, Monti P, Allavena P, Sironi M, Soldini L, Leone BE, Socci C, Di Carlo VGlucocorticoids affect human dendritic cell differentiation and maturationJ Immunol.(1999 Jun 1)
      86.^Lin KW, Chen SC, Chang FH, Kung JT, Hsu BR, Lin RHThe roles of interleukin-1 and interleukin-1 receptor antagonist in antigen-specific immune responsesJ Biomed Sci.(2002 Jan-Feb)
      87.^Chintalwar G, Jain A, Sipahimalani A, Banerji A, Sumariwalla P, Ramakrishnan R, Sainis KAn immunologically active arabinogalactan from Tinospora cordifoliaPhytochemistry.(1999 Nov)
      89.^Chopra A, Saluja M, Tillu G, Venugopalan A, Narsimulu G, Handa R, Bichile L, Raut A, Sarmukaddam S, Patwardhan BComparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled studyClin Rheumatol.(2012 Feb)
      90.^Lekurwale PS, Pandey K, Yadaiah PManagement of Amavata with 'Amrita Ghrita': A clinical studyAyu.(2010 Oct)
      92.^Akhtar SUse of Tinospora cordifolia in HIV infectionIndian J Pharmacol.(2010 Feb)
      93.^Jayaganthan P, Perumal P, Balamurugan TC, Verma RP, Singh LP, Pattanaik AK, Kataria MEffects of Tinospora cordifolia supplementation on semen quality and hormonal profile in ramsAnim Reprod Sci.(2013 Jul)
      94.^Kapur P, Pereira BM, Wuttke W, Jarry HAndrogenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaPPhytomedicine.(2009 Jun)
      96.^Nagarkatti DS, Rege NN, Desai NK, Dahanukar SAModulation of Kupffer cell activity by Tinospora cordifolia in liver damageJ Postgrad Med.(1994 Apr-Jun)
      98.^Orion E, Marcos B, Davidovici B, Wolf RItch and scratch: scabies and pediculosisClin Dermatol.(2006 May-Jun)
      99.^Vorou R, Remoudaki HD, Maltezou HCNosocomial scabiesJ Hosp Infect.(2007 Jan)