Quick Navigation

Griffonia simplicifolia

Griffonia simplicifolia is an African shrub and a source of the compound 5-HTP. It has anxiety and appetite-reducing effects.

Our evidence-based analysis on griffonia simplicifolia features 21 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Summary of Griffonia simplicifolia

Primary Information, Benefits, Effects, and Important Facts

Griffonia simplicifolia is a West African shrub. Griffonia simplicifolia is the largest source of the compound 5-HTP. Its seeds contain up to 20% 5-HTP, by weight.

Studies that have been done on Griffonia simplicifolia suggest that when supplemented as an herb, it may rival the effects of supplementing 5-HTP in isolation.

However, further research is needed to confirm this effect. There may be other bioactives in the plant that are still undiscovered.

Additional studies are needed to determine whether supplementing Griffonia simplicifolia is truly comparable to supplementing 5-HTP.

Get unbiased information on what works

At Examine.com, we pride ourselves on basing all our recommendations on evidence. It’s why we don’t sell any advertising or supplements — so that you know that our analysis is unbiased.

If you’re tired of wasting time and money on supplements that don’t work, our 17 Supplement Guides will help you figure out precisely what to take — and what to skip — based on your health goals and the latest scientific evidence.

Join over 50,000 people who rely on Examine.com's unbiased and science-based analysis.


I want unbiased recommendations »

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Further research is needed to determine the optimal human dose of Griffonia simplicifolia. The lowest effect dose for rats is 25mg/kg of bodyweight, which is about 4mg/kg of Griffonia simplicifolia extract, assuming 20% 5-HTP content. This translates to following human doses:

• 275mg Griffonia(55mg of 5-HTP) for a 150lb person

• 350mg Griffonia (70mg of 5-HTP) for a 200lb person

• 450mg Griffonia (90mg of 5-HTP) for a 250lb person

It is unknown whether Griffonia simplicifolia has other bioactives other than 5-HTP. The human dosages listed above are derived from rodent studies, and are not optimal, which is why they are different from the optimal dose of 5-HTP.

Things to Note

Is a Form Of

Other Functions:

Primary Function:

Do Not Confuse With

5-HTP (Bioactive)

Caution Notice

Due to being a vessel for 5-HTP in sufficient amounts, the cautions on the 5-HTP page will extend to supplementation with Griffonia Simplicifolia and this herb should not be used alongside cognitive drugs and particularly SSRIs.

Tired of misinformation? Get unbiased info on supplements.

At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.

Join over 250,000 people who’ve learned about effective versus overrated supplements, supplement buying tips, and how to combine supplements for safety and efficacy.

Click here to see all 21 references.