Clubmoss

Last Updated: November 17 2022

Clubmoss (common word to refer to the Lycopodium/Huperzia genera of plants) is a collection of plants with traditional usage in promoting memory formation, and appears to have a large collection of unique alkaloids. Its main bioactive is Huperzine-A.

Clubmoss is most often used for



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1.

Sources and Composition

1.1

Sources

The Lycopodium genus (of the family Lycopodiaceae) is a genus of herbs more commonly known as Clubmoss or Toothed Clubmoss, the genus (Lycopodium) is synonymous with Huperzeria in reference to the main bioactive of clubmoss being Huperzine-A (also known as shuangyiping[1]); other less common synonyms for this plant include Devil's Ash, Devil's Claw, or Ground Pine.[2]

The related herb Lycopodium serratum appears to be a traditional chinese medicine for memory[3] and the overall genus includes the species of serratum or serrata, alpinum, annotinum, clavatum, complanatum subspecies chamaecyparissus, obscurum, and selago.[2]

The genera of Lycopodium (also known as Huperzeria) is traditionally used for memory improvement and cognition, and several species of this plant appear to have traditional usage

1.2

Composition

Plants of the Lycopodium genera tend to contain (species stated if only found in those species, otherwise the compound has been found in various species and is thought to be general):

  • Huperzine-A (shuangyiping; commonly seen as the main bioactive)
  • The C16N alkaloids lycopodane, lycopodine, alopecurane, fawcettimane, fawcettidane, serratinane and magellanane[4][5]
  • Lycoflexine and lycoposerramine[5]
  • Lobscurinol and epilobscurinol, as well as lycobscurines A-C (Lycopodium obscurum)[6][7]
  • The C16N2 alkaloids flabellidane, phlegmarane and cernuane[8][4]
  • Lycopoclavamine A (Lycopodium clavatum)[9]
  • Lycoposquarrosamine-A[9]
  • Lycospidine A[10] as well as Lyconadins D and E (from Lycopodium complanatum)[11]
  • Complanadine alkaloids, including Complanadine A,[12] B,[13], C.[14] D,[14] and E[11]
  • Ferulic Acid (0.443% dry weight)[15]

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There appears to be a large amount of structurally unique alkaloids in this plant. Although their bioactivity is not completely elucidated right now, they are unique to the genera of Lycopodium/Huperzeria and there is more than just Huperzine-A

2.

Neurology

2.1

Cholinergic Neurotransmission

2.2

Neurogenesis

Complanadine structures from lycopodium complanatum have been found to induce mRNA for NGF at a concentration of 100μM by 3.9 (complanadine A), 2.3 (complanadine B), 2.4 (complanadine D), and 2.8-fold (complanadine E).[11] This has been reported previously with complanadines C and D.[14]

Complanadine structures (unique to lycopodium complanatum) may increase NGF levels, but this occurs at quite a high concentration and may not be practically relevant for supplementation of the plant

3.

Inflammation and Immunology

3.1

Interventions

A study using fractions of Lycopodium clavatum in a mouse model of acetic-acid induced capillary permeability increases, it was found that the most active fragment (500mg/kg chloroform extract causing 32.1% inhibition) was less potent than the reference drug of indomethacin at 10mg/kg (44.6% inhibition).[2] This fraction was mostly (84.5%) lycopodine.[2]

Potential anti-inflammatory effects, but seems pretty weak relative to reference drugs and requires quite a high dosage as well

4.

Interactions with Aesthetics

4.1

Skin

Lycopodium clavatum appears to have traditional usage in Turkey for wound healing properties[2] and has usage for burn healing as well.[16]

References
2.^Orhan I, Küpeli E, Sener B, Yesilada EAppraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum LJ Ethnopharmacol.(2007 Jan 3)
4.^Ayer WAThe lycopodium alkaloidsNat Prod Rep.(1991 Oct)
5.^Itoh N, Iwata T, Sugihara H, Inagaki F, Mukai CTotal syntheses of (±)-fawcettimine, (±)-fawcettidine, (±)-lycoflexine, and (±)-lycoposerramine-qChemistry.(2013 Jun 24)
6.^Pan K, Luo JG, Kong LYThree new Lycopodium alkaloids from Lycopodium obscurumJ Asian Nat Prod Res.(2013 May)
10.^Cheng JT, Liu F, Li XN, Wu XD, Dong LB, Peng LY, Huang SX, He J, Zhao QSLycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatumOrg Lett.(2013 May 6)
11.^Ishiuchi K, Kubota T, Ishiyama H, Hayashi S, Shibata T, Mori K, Obara Y, Nakahata N, Kobayashi JLyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatumBioorg Med Chem.(2011 Jan 15)
14.^Ishiuchi K, Kubota T, Mikami Y, Obara Y, Nakahata N, Kobayashi JComplanadines C and D, new dimeric alkaloids from Lycopodium complanatumBioorg Med Chem.(2007 Jan 1)