California Poppy

•Last Updated: September 28 2022

California Poppy is an herb that has some bioactive alkaloids which may be nootropic or cognitive enhancing in nature; It is currently in the exploratory stages of research.

dosage

California Poppy is most often used for

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Kamal Patel, MPH, MBA

Last Updated: September 28 2022

summary
Dosage information
Research breakdown
References

Summary

California Poppy is a common plant in North and South America that has some traditional usage as a sedative and anxiolytic when made as a tea. Two rat studies have observed sedatory and anxiolytic actions, and one human study showed some promise to this claim but conclusions cannot be drawn since it also used another herb in conjunction with California Poppy.

In the preliminary stages of research, the unique alkaloid profile of California Poppy appears to interact with a variety of receptors in potent ways. The vast majority of these leads have not been further investgiated, and conclusions (especially on Serotonin) cannot be drawn at this point in time.

Currently, California Poppy is too preliminary to support any supplemental usage.

What else is California Poppy known as?

Note that California Poppy is also known as:

California Poppy
Eschscholzia Californica

Dosage information

There is currently not enough evidence to support an optimal dose of California Poppy. The best bet may to simply make tea, which has been apparently used as an anxiolytic and sedative by some people.

Research Breakdown

1

Sources and Composition

1.1

Composition

2

Pharmacology

2.1

Metabolism

2.2

Enzymatic Interactions

3

Neurology

3.1

Anxiety

3.2

Sedation

3.3

Acetylcholine

3.4

Serotonin

3.5

Dopamine

3.6

Adrenergic

3.7

Histamine

3.8

Adenosine

3.9

Cannabinoids

References

1.^Cahlíková L, Kucera R, Host'álková A, Klimes J, Opletal LIdentification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MSNat Prod Commun.(2012 Oct)

2.^Véliz D, Gauci R, Bustamante ROCharacterization of novel microsatellite markers for Eschscholzia californica (Papaveraceae), an invasive species in central ChileAm J Bot.(2012 Sep)

3.^Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollom MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JLAlkaloids from Eschscholzia californica and their capacity to inhibit binding of {3H}8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in VitroJ Nat Prod.(2006 Mar)

4.^Tanahashi T, Zenk MHNew hydroxylated benzo{c}phenanthridine alkaloids from Eschscholtzia californica cell suspension culturesJ Nat Prod.(1990 May-Jun)

5.^Barrell PJ, Wakelin AM, Gatehouse ML, Lister CE, Conner AJInheritance and epistasis of loci influencing carotenoid content in petal and pollen color variants of california Poppy (Eschscholzia californica Cham.)J Hered.(2010 Nov-Dec)

6.^Paul LD, Maurer HHStudies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometryJ Chromatogr B Analyt Technol Biomed Life Sci.(2003 Jun 5)

7.^Kleber E, Schneider W, Schäfer HL, Elstner EFModulation of key reactions of the catecholamine metabolism by extracts from Eschscholtzia californica and Corydalis cavaArzneimittelforschung.(1995 Feb)

8.^Hanus M, Lafon J, Mathieu MDouble-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disordersCurr Med Res Opin.(2004 Jan)

9.^Rolland A, Fleurentin J, Lanhers MC, Younos C, Misslin R, Mortier F, Pelt JMBehavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic propertiesPlanta Med.(1991 Jun)

10.^Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier FNeurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae)Phytother Res.(2001 Aug)

11.^Cahlíková L, Macáková K, Kunes J, Kurfürst M, Opletal L, Cvacka J, Chlebek J, Blundene GAcetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae)Nat Prod Commun.(2010 Jul)

Primary Use

Secondary Use

Mental Health