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Things to Note
Brassaiopsis glomerulata is a plant that appears to have traditional usage in treating rheumatism and back pain in the elderly. Despite these claims, the first investigations in the plant were to investigate the presence of low molecular weight aromatase inhibitors.
There appear to be a few aromatase inhibitors in this compound with one of them showing a fair bit of potency, but there is currently a lack of evidence to support the usage of this plant orally for the purpose of aromatase inhibition.
How to Take
Recommended dosage, active amounts, other details
There is currently insufficient evidence to support an oral dose of Brassaiopsis glomerulata
Table of Contents:
Sources and Composition
Interactions with Hormones
Brassaiopsis glomerulata (of the family Araliaceae) is a deciduous tree found in the north Vietnam regions of Phucyen and Vinhphuc; It appears to have limited medicinal usage for treating rheumatism and back pain in elderly persons.
Stigmasterol, 6β-hydroxystimasta-4-en-3-one, 7β-hydroxy-4,22-stigmastadien-3-one
N-benzoyl-L-phenylalaninyl-N-benzoyl-L-phenylalaninate, N-acetyl-L-phenylalaninyl-N-benzoyl-L-phenylalaninate, and N-benzoyl-L-phenylalanine methyl ester
Spinasterone and spinasterol
Linoleic acid (fatty acid)
Not fully elucidated, but appears to have a general assortment of triterpenoids that may be unique to this plant
2.1. Enzymatic Interactions
In vitro at 20mcg/mL, a hexane-soluble extract appears to reduce aromatase activity t0 6.9-7.2% of the activity of untreated control cells, which appeared to also apply to the ethyl acetate fraction (37-59.3% of control). When looking at molecules which could underlie this aromatase inhibition, it was found that (−)-dehydrololiolide (21.8% of control activity at 50μM in a cell culture) was able to potently inhibit aromatase to a degree that was not statistically different than letrozole (10nM); additionally, N-benzoyl-L-phenylalanine methyl ester (33.3% of control activity) and 6β-Hydroxystigmasta-4-en-3-one was weaker in inhibiting aromatase yet still active. The inhibition was thought to be indirect, as all compounds were fairly inactive in enzyme only assays (showing activity in cellular assays).
Although linoleic acid was more effective than the reference drug aminoglutethimide in an enzyme assay, it was inactive in a cell assay; this may be due to false positives associated with fatty acids in cell-free cultures.
Some compounds of Brassaiopsis glomerulata_ appear to be able to inhibit the aromatase enzyme
3Interactions with Hormones
It has been noted that active components of Brassaiopsis glomerulata can inhibit the aromatase enzyme in vitro, but no evidence currently exists to support an increase in testosterone or decrease in estrogen in a living system.
Scientific Support & Reference Citations
Kiem PV, et al. Lupane-triterpenes from the leaves of Brassaiopsis glomerulata.
Arch Pharm Res. (2003)
Balunas MJ, et al. Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae).
Phytochem Lett. (2009)
Balunas MJ, et al. Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.
J Nat Prod. (2006)