BPC-157 may support the healing of various tissues such as tendons, joints, nerves, the intestinal tract, the stomach, and skin, based on studies in rodents and cultured cells. However, more research is needed to determine its potential benefits in humans.
What are BPC-157’s main benefits?
What are BPC-157’s main drawbacks?
BPC-157’s potential drawbacks are uncertain, given the lack of human evidence. No clear toxicity or negative side effects have been reported in studies conducted in rodents,[4][5][1] but this research is limited. Therefore, the biggest drawback of BPC-157 is that there is insufficient evidence of its safety.
How does BPC-157 work?
BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[2][6][7]
BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[8]
What is BPC-157?
Body Protection Compound 157 (BPC-157) is a peptide composed of 15 amino acids. Although the researchers who patented BPC-157 say that it was derived from a stomach protein, this claim isn’t well-substantiated.[9] BPC-157 is thought to improve the repair of damaged tissues, although there is currently no human evidence to support this hypothesis.[1]
What are other names for BPC-157?
Note that BPC-157 is also known as:
- PL 14736
- PL-10
- Bepecin
BPC-157 should not be confused with:
- TB-500
Dosage information
The closest possible recommended dose is based on rat studies where oral administration showed benefit, as most studies administer the supplement via injection. The oral dose that was effective in rats, 10 μg/kg, is estimated to be equivalent to 1.6 μg/kg, or:
- 110 μg for a 150lb person
- 145 μg for a 200lb person
- 180 μg for a 250lb person
There are currently no human pharmacokinetic studies to assess species differences.
Frequently asked questions
What are BPC-157’s main benefits?
What are BPC-157’s main drawbacks?
BPC-157's main drawback is the lack of human evidence on its safety; studies in rodents have not reported clear toxicity or negative side effects. The limited research means that its potential drawbacks remain uncertain.
BPC-157’s potential drawbacks are uncertain, given the lack of human evidence. No clear toxicity or negative side effects have been reported in studies conducted in rodents,[4][5][1] but this research is limited. Therefore, the biggest drawback of BPC-157 is that there is insufficient evidence of its safety.
How does BPC-157 work?
BPC-157 works through various mechanisms, including promoting nitric oxide synthesis, activating tissue repair cells, stimulating growth factor synthesis, and inhibiting inflammation. Although peptides typically have limited absorption when taken orally, studies suggest that BPC-157 may still exert systemic effects even when ingested.
BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[2][6][7]
BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[8]
What is BPC-157?
BPC-157 is a peptide made up of 15 amino acids and is purportedly derived from a stomach protein, though this claim lacks strong evidence. It is believed to enhance tissue repair, but there is currently no human evidence to confirm this effect.
Body Protection Compound 157 (BPC-157) is a peptide composed of 15 amino acids. Although the researchers who patented BPC-157 say that it was derived from a stomach protein, this claim isn’t well-substantiated.[9] BPC-157 is thought to improve the repair of damaged tissues, although there is currently no human evidence to support this hypothesis.[1]
Update History
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