BPC-157 is a synthetic peptide that is being investigated for its regenerative effects. It shows high efficacy for rats suffering toxic or surgical trauma, but there is currently little evidence that it provides benefits for people.
BPC-157 is most often used for
Last Updated:November 15, 2023
BPC-157’s potential drawbacks are uncertain, given the lack of human evidence. No clear toxicity or negative side effects have been reported in studies conducted in rodents,[4][5][1] but this research is limited. Therefore, the biggest drawback of BPC-157 is that there is insufficient evidence of its safety.
BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[2][6][7]
BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[8]
Body Protection Compound 157 (BPC-157) is a peptide composed of 15 amino acids. Although the researchers who patented BPC-157 say that it was derived from a stomach protein, this claim isn’t well-substantiated.[9] BPC-157 is thought to improve the repair of damaged tissues, although there is currently no human evidence to support this hypothesis.[1]
The closest possible recommended dose is based on rat studies where oral administration showed benefit, as most studies administer the supplement via injection. The oral dose that was effective in rats, 10 μg/kg, is estimated to be equivalent to 1.6 μg/kg, or:
There are currently no human pharmacokinetic studies to assess species differences.
Corrected an error
We said that BPC-157 was derived from a "stomach protein", without elaborating on what protein that was. The papers on this subject are similarly unclear, so we adjusted our wording to show that, while some studies suggest that BPC-157 is derived from a stomach protein, there's really no indication this is the case.
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