BPC-157

Last Updated: November 28 2022

BPC-157 is a synthetic peptide that is being investigated for its regenerative effects. It shows high efficacy for rats suffering toxic or surgical trauma, but there is currently no evidence that it provides benefits for people.

BPC-157 is most often used for

What are BPC-157’s main benefits?

More research is needed to determine whether BPC-157 has any potential benefits in humans. Studies conducted in rodents and cultured cells have suggested that BPC-157 may support the healing of various tissues, including tendons, joints, nerves, the intestinal tract, the stomach, and skin.[37][28][38]

What are BPC-157’s main drawbacks?

BPC-157’s potential drawbacks are uncertain, given the lack of human evidence. No clear toxicity or negative side effects have been reported in studies conducted in rodents,[39][40][37] but this research is limited. Therefore, the biggest drawback of BPC-157 is that there is insufficient evidence of its safety.

How does BPC-157 work?

BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[28][19][41]

BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[42]

How does BPC-157 work?

BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[28][19][41]

BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[42]

What else is BPC-157 known as?
Note that BPC-157 is also known as:
  • PL 14736
  • PL-10
  • Bepecin
BPC-157 should not be confused with:
  • TB-500
Dosage information

The closest possible recommended dose is based on rat studies where oral administration showed benefit, as most studies administer the supplement via injection. The oral dose that was effective in rats, 10 μg/kg, is estimated to be equivalent to 1.6 μg/kg, or:

  • 110 μg for a 150lb person
  • 145 μg for a 200lb person
  • 180 μg for a 250lb person

There are currently no human pharmacokinetic studies to assess species differences.

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References
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