Does vitamin C increase paraoxonase 1 activity in chronic kidney disease? Original paper

In this meta-analysis, supplementation with vitamin C in participants with chronic kidney disease who were undergoing hemodialysis was associated with higher paraoxonase 1 activity.

This Study Summary was published on February 6, 2024.

Quick Summary

In this meta-analysis, supplementation with vitamin C in participants with chronic kidney disease who were undergoing hemodialysis was associated with higher paraoxonase 1 activity.

What was studied?

The association between supplementation with vitamin C and the activity of paraoxonase 1 (PON1; an antioxidant enzyme with suspected cardioprotective properties[1]) in the context of chronic kidney disease (CKD).

Who was studied?

A total of 92 participants (average ages of 39–66) with CKD who were undergoing hemodialysis for 4–5 hours, 3 times per week.

How was it studied?

A meta-analysis of 4 studies (2 before-and-after study and 2 case-control studies) was performed. The studies were conducted in the United States, Taiwan, Italy, and Turkey. Vitamin C was administered orally (2 studies) or intravenously (2 studies) once a day (1 study) or at the end of each dialysis session (3 studies) at a dose of 100–500 milligrams. The intervention duration ranged from 2 to 6 months.

What were the results?

Supplementation with vitamin C was associated with higher (better) PON1 activity.

Neither risk of bias nor publication bias were assessed.

This Study Summary was published on February 6, 2024.

References

  1. ^Shunmoogam N, Naidoo P, Chilton RParaoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.Vasc Health Risk Manag.(2018)