Curcumin may reduce body weight and improve cardiometabolic outcomes Original paper

In this meta-analysis of randomized controlled trials, supplementation with curcumin slightly reduced body weight and improved cardiometabolic biomarkers in adults with metabolic disorders

This Study Summary was published on February 8, 2024.

Quick Summary

In this meta-analysis of randomized controlled trials, supplementation with curcumin slightly reduced body weight and improved cardiometabolic biomarkers in adults with metabolic disorders

What was studied?

The effect of supplementation with curcumin on a range of outcomes in the context of metabolic disorders.

Specifically, the following outcomes were studied:

Who was studied?

A total of 2,462 men and women (average ages of 35–70), including 1,455 participants with impaired glycemic control (prediabetes or type 2 diabetes), 701 with metabolic syndrome, and 306 with hyperlipidemia.

How was it studied?

A meta-analysis of 31 randomized controlled trials was performed. The trials were conducted in Iran, Thailand, China, Italy, Pakistan, Germany, Australia, Japan, and Brazil. Four trials administered nanocurcumin (a form of curcumin with high-bioavailability) at a daily dose of 80 mg, 14 trials used other curcumin formulations with high bioavailability (such as curcumin phytosome and curcumin + piperine), and 13 trials used curcumin formulations with low bioavailability (such as turmeric powder and curcumin powder). The comparator was a placebo in all of the trials. The intervention duration ranged from 4 to 36 weeks.

What were the results?

Compared to placebo, supplementation with curcumin reduced (improved) body weight (−0.94 kg), BMI (−0.40), fasting glucose (−0.50 mg/dL), HbA1c (−0.42%), insulin (−1.70 µIU/mL), insulin resistance, and hs-CRP (−1.11 mg/L), and increased (improved) HDL cholesterol (+1.73 mg/dL).

The risk of bias was unclear in all of the trials.

Anything else I need to know?

Although the researchers performed dose-response analyses and subgroup analyses based on the type of curcumin formulation used, the benefits of curcumin could not be clearly attributed to a specific type of formulation or range of doses.

This Study Summary was published on February 8, 2024.