Are artificial sweeteners linked to bladder cancer? Original paper

In this meta-analysis of 21 observational studies, consumption of artificial sweeteners was not associated with bladder cancer risk.

This Study Summary was published on February 5, 2024.

Quick Summary

In this meta-analysis of 21 observational studies, consumption of artificial sweeteners was not associated with bladder cancer risk.

What was studied?

The association between the intake of artificial sweeteners and the risk of bladder cancer.

Who was studied?

116,568 participants, of whom 44,497 used artificial sweeteners and 13,682 had bladder cancer.

How was it studied?

A meta-analysis was performed of 21 observational studies (19 case-control studies and 2 case series), which were conducted in North America (13 studies), Europe (4 studies), Asia (3 studies), and multiple countries (1 study). The most frequently investigated artificial sweetener was saccharin. However, almost half of the studies did not specify the artificial sweetener investigated.

What were the results?

There was no difference in the incidence of bladder cancer between the participants who consumed artificial sweeteners and the participants who did not. Also, there was no difference in the frequency of artificial sweetener consumption between the participants with bladder cancer and the participants without bladder cancer.

Methodological quality was rated high in 13 of the studies and moderate in 8 studies.

This Study Summary was published on February 5, 2024.