Dietary supplements for cervical cancer Original paper

In this systematic review of mostly randomized controlled trials, supplementing with folate, vitamin D, zinc, and omega-3 fatty acids seemed to have beneficial effects in participants with cervical cancer or at risk of cervical cancer.

This Study Summary was published on November 30, 2023.

Quick Summary

In this systematic review of mostly randomized controlled trials, supplementing with folate, vitamin D, zinc, and omega-3 fatty acids seemed to have beneficial effects in participants with cervical cancer or at risk of cervical cancer.

What was studied?

The effect of various supplements on outcomes in participants with cervical cancer or at risk of cervical cancer.

The outcomes were recurrence of cervical cancer, regression of precancerous cervical cancer, and improvements in the health of participants who were receiving cancer treatment.

Who was studied?

A total of 1,452 women (over age 18) with cervical cancer or cervical intraepithelial neoplasia (CIN; abnormal growth of cervical cells, a precancerous condition).

CIN is graded from 1 to 3, where 3 represents the worst severity of the condition.

How was it studied?

In this systematic review of 19 studies, 18 of the studies were randomized controlled trials (RCTs), and 1 study was a cohort study. Six studies were conducted in Iran, 2 studies each were conducted in Indonesia, the United States, and Mexico, and 1 study each was conducted in Turkey, Germany, Brazil, Japan, Thailand, India, and Myanmar.

The supplements studied were vitamin A, beta-carotene, folic acid, vitamin B12, vitamin C, vitamin E, selenium, omega-3 fatty acids, omega-6 fatty acids, vitamin D, zinc, probiotics, arginine, glutamine, resistant starch, coenzyme Q10, and multivitamins.

The comparators (controls) included no supplementation, placebo supplementation, and comparison between participants with and without cancer who all received supplements.

What were the results?

Supplementation with zinc sulfate increased the resolution of cervical lesions compared to the control interventions.[1] In two different RCTs, a greater percentage of participants who were given folate[2] and vitamin D[3] had resolution of grade 1 CIN, compared to control groups.

In one trial that used a dosage of 50,000 IU of vitamin D every 2 weeks for 6 months, grade 2–3 CIN rates were not reduced.[4] In another RCT, a multicomponent supplement (with beta-carotene, selenium, yeast, zinc, Ginkgo biloba, ginseng, vitamin C, and vitamin E) did not reduce cervical cancer recurrence at 4 years.[5]

Participants with cervical cancer supplemented with omega-3 fatty acids (2,000 mg/day of eicosapentaenoic acid and 450 mg/day of docosahexaenoic acid) lost less muscle mass and had fewer cases of chemotherapy toxicity than participants in the control group.[6]

This Study Summary was published on November 30, 2023.

References

  1. ^Hale Ayatollahi, Elham Rajabi, Zahra Yekta, Zahra JalaliEfficacy of Oral Zinc Sulfate Supplementation on Clearance of Cervical Human Papillomavirus (HPV); A Randomized Controlled Clinical TrialAsian Pac J Cancer Prev.(2022 Apr 1)
  2. ^Asemi Z, Vahedpoor Z, Jamilian M, Bahmani F, Esmaillzadeh AEffects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.Nutrition.(2016-Jun)
  3. ^Vahedpoor Z, Jamilian M, Bahmani F, Aghadavod E, Karamali M, Kashanian M, Asemi ZEffects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial.Horm Cancer.(2017-Feb)
  4. ^Vahedpoor Z, Mahmoodi S, Samimi M, Gilasi HR, Bahmani F, Soltani A, Sharifi Esfahani M, Asemi ZLong-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial.Ann Nutr Metab.(2018)
  5. ^Álvarez-Altamirano K, Mendoza-Hernández AN, Carcoba-Tenorio C, García-García JA, Fuchs-Tarlovsky VLa suplementación con antioxidantes durante el tratamiento oncológico no tiene efecto sobre la recurrencia de cáncer cervicouterinoNutr Hosp.(2016-Mar-25)
  6. ^Aredes MA, da Camara AO, de Paula NS, Fraga KYD, do Carmo MDGT, Chaves GVEfficacy of ω-3 supplementation on nutritional status, skeletal muscle, and chemoradiotherapy toxicity in cervical cancer patients: A randomized, triple-blind, clinical trial conducted in a middle-income country.Nutrition.(2019)