Taking flavonoids may reduce symptoms of depression and anxiety Original paper

In this meta-analysis of 11 randomized controlled trials, supplementation with flavonoids reduced symptoms of depression and anxiety.

This Study Summary was published on February 9, 2024.

Quick Summary

In this meta-analysis of 11 randomized controlled trials, supplementation with flavonoids reduced symptoms of depression and anxiety.

What was studied?

The effect of supplementation with flavonoids on symptoms of depression and anxiety.

Who was studied?

969 participants (average ages of 14–68; 867 women, 102 men; 905 adults, 64 adolescents) with symptoms of anxiety and/or depression.

How was it studied?

A meta-analysis was performed of 11 randomized controlled trials, which were conducted in Australia (2 trials), Italy (2 trials), Japan (2 trials) and in Brazil, China, the United Kingdom, and the United States (1 trial each); the country was not reported for 1 study.

The interventions were isoflavones in 6 trials, flavonoid extracts in 4 trials, and anthocyanins in 1 trial. The daily dose of flavonoids ranged from 15 to 960 mg. The comparator was a placebo in all of the trials.

The intervention duration ranged from 1 week to 2 years.

What were the results?

Supplementation with flavonoids reduced symptoms of anxiety and depression to a moderate degree. However, there was considerable heterogeneity in the analyses of both of the outcomes, which persisted in subgroup analyses.

The risk of bias was unclear in 7 trials, low in 3 trials, and high in 1 trial.

Anything else I need to know?

Because of methodological differences among the trials included in the meta-analysis, the most effective type of flavonoids, optimal dosing regimen, and specific population that would benefit most from supplementation were not established.

This Study Summary was published on February 9, 2024.