Magnesium intake and all-cause mortality after stroke Original paper

In this cohort study, a greater intake of magnesium was associated with lower all-cause mortality risk among stroke survivors.

This Study Summary was published on February 9, 2024.

Quick Summary

In this cohort study, a greater intake of magnesium was associated with lower all-cause mortality risk among stroke survivors.

What was studied?

The association between magnesium intake and all-cause mortality in people with a history of stroke.

Who was studied?

917 adults (average age of 57; 50.2% women, 49.8% men) in the United States with a history of stroke, as reported by a doctor or other health professional.

How was it studied?

This cohort study used two 24-hour dietary recall interviews from the 2007–2018 cycles of the National Health and Nutrition Examination Survey[1]) to assess dietary and supplemental magnesium intake. Total magnesium intake was adjusted for energy (calorie) intake, and the participants were divided into four groups (quartiles) based on their intake. The participants in the highest quartile consumed at least 18.5 mg of magnesium per 100 kilocalories (kcal) daily; the lowest quartile consumed 12 mg of magnesium or less per 100 kcal daily. Approximately 70% of the men and 74% of the women had an insufficient total magnesium intake (<350 mg/day for men and <300 mg/day for women).

The average follow-up period was 5.3 years, and mortality was determined by public death records.

The analyses were adjusted for confounders, including age, ethnicity, sex, and other sociodemographic characteristics, as well as dietary pattern, lifestyle factors, and medical history.

What were the results?

A greater magnesium intake was associated with lower all-cause mortality risk. Each milligram of magnesium per 100 kcal was associated with a 3% reduction in risk. The highest quartile had a 40% lower mortality risk, compared with the lowest quartile.

Anything else I need to know?

The motivation behind this study is that adequate magnesium intake has previously been linked to a lower risk of stroke and all-cause mortality, but the relationship between magnesium and mortality risk after stroke is not well understood.[2]

This Study Summary was published on February 9, 2024.

References

  1. ^Chen TC, Clark J, Riddles MK, Mohadjer LK, Fakhouri THINational Health and Nutrition Examination Survey, 2015-2018: Sample Design and Estimation Procedures.Vital Health Stat 2.(2020-Apr)
  2. ^Zhao B, Zeng L, Zhao J, Wu Q, Dong Y, Zou F, Gan L, Wei Y, Zhang WAssociation of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis.BMJ Open.(2020-Mar-19)