Anthocyanins improve metabolic health in type 2 diabetes Original paper

In this meta-analysis of randomized controlled trials, supplementation with anthocyanins or anthocyanin-rich fruits/fruit extracts improved several biomarkers of metabolic health.

This Study Summary was published on February 2, 2024.

Quick Summary

In this meta-analysis of randomized controlled trials, supplementation with anthocyanins or anthocyanin-rich fruits/fruit extracts improved several biomarkers of metabolic health.

What was studied?

The effect of anthocyanins or anthocyanin-rich fruits/fruit extracts on the levels of glycated hemoglobin (HbA1c; a biomarker of glycemic control; primary outcome) in the context of type 2 diabetes (T2D).

The secondary outcomes were other biomarkers of glycemic control (insulin resistance and the levels of fasting glucose, 2-hour postprandial (postmeal) glucose, and fasting insulin), blood lipids (the levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides), and systolic and diastolic blood pressure.

Who was studied?

A total of 703 men and women (average ages of 48–67) with T2D.

How was it studied?

A meta-analysis of 13 randomized controlled trials was performed. The trials were conducted in Iran (6 trials), China (4 trials), the United States (1 trial), Canada (1 trial), and Japan (1 trial). Two trials administered anthocyanins, whereas 11 trials administered anthocyanin-rich fruits/fruit extracts. The daily dose of anthocyanins ranged from 0.672 mg to 1,500 mg. The comparator was placebo in all trials. The intervention duration ranged from 4 to 24 weeks.

What were the results?

Supplementation with anthocyanins or anthocyanin-rich fruits/fruit extracts reduced the levels of glycated hemoglobin by 0.31% (high certainty of evidence), fasting glucose by 0.63 mmol/L or 11.3 mg/dL (high certainty of evidence), 2-hour postprandial glucose by 1.6 mmol/L or 28.8 mg/dL (moderate certainty of evidence), LDL cholesterol by 0.26 mmol/L or 10 mg/dL (moderate certainty of evidence), and triglycerides by 0.45 mmol/L or 17.4 mg/dL (moderate certainty of evidence).

This Study Summary was published on February 2, 2024.