Homocysteine is a biomarker of cardiovascular disease, and it is thought that higher circulating levels of homocysteine are indicative of a higher risk for cardiovascular incidents.

This page features 4 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Homocysteine
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
B Trimethylglycine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Vitamin B2
C Chlorogenic Acid
C Creatine
C Fish Oil
C Green Coffee Extract
C Cocoa Extract
C Garlic
C Hesperidin
C Red Clover Extract
C S-Adenosyl Methionine
C Vitamin B12
C Vitamin E


  1. Gariballa SE, Forster SJ, Powers HJ Effects of mixed dietary supplements on total plasma homocysteine concentrations (tHcy): a randomized, double-blind, placebo-controlled trial . Int J Vitam Nutr Res. (2012)
  2. Rocco A, et al Vitamin B12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus . Gut. (2013)
  3. Hill MH, et al A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status . J Nutr. (2013)
  4. Huijts M, et al Effects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar stroke . Int Psychogeriatr. (2013)

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