This page on Homocysteine is currently marked as in-progress. We are still compiling research.
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Scientific Information on Homocysteine
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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Homocysteine
| Grade | Level of Evidence |
|---|---|
| A | Robust research conducted with repeated double blind clinical trials |
| B | Multiple studies where at least two are double-blind and placebo controlled |
| C | Single double blind study or multiple cohort studies |
| D | Uncontrolled or observational studies only |
| Level of Evidence | Supplement | Change | Magnitude of Effect Size | Scientific Consensus | Comments |
|---|---|---|---|---|---|
| C | Creatine |   Minor | 100% See study | Decrease in homocysteine (biomarker of inflammatory cardiovascular disease) was present, but not to a remarkable magnitude | |
| C | Fish Oil | Minor | 100% See 2 studies | May decrease homocysteine content | |
| C | Chlorogenic Acid | Minor | 100% See study | Somewhat high acute spike of homocysteine, which is normally a negative thing. Practical significance of this unknown | |
| C | S-Adenosyl Methionine | No significant alterations in plasma homocysteine occur following supplemental SAMe ingestion | |||
| C | Green Coffee Extract | Minor | 100% See study | Decrease in homocysteine noted, thought to be indicative of cardioprotection |
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