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Homocysteine is a biomarker of cardiovascular disease, and it is thought that higher circulating levels of homocysteine are indicative of a higher risk for cardiovascular incidents.

This page features 15 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Homocysteine
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
B Trimethylglycine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Vitamin B2
C Chlorogenic Acid
C Creatine
C Fish Oil
C Green Coffee Extract
C Cocoa Extract
C Garlic
C Hesperidin
C Red Clover Extract
C S-Adenosyl Methionine
C Vitamin B12
C Vitamin E


  1. Nebbioso M1, et al Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial . Eur Rev Med Pharmacol Sci. (2013)
  2. Boehnke C1, et al High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre . Eur J Neurol. (2004)
  3. Maizels M, Blumenfeld A, Burchette R A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial . Headache. (2004)
  4. Schoenen J1, Jacquy J, Lenaerts M Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial . Neurology. (1998)
  5. Condò M1, et al Riboflavin prophylaxis in pediatric and adolescent migraine . J Headache Pain. (2009)
  6. McNulty H1, et al Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism . Circulation. (2006)
  7. Wilson CP1, et al Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up . Am J Clin Nutr. (2012)
  8. Horigan G1, et al Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR . J Hypertens. (2010)
  9. Wilson CP1, et al Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial . Hypertension. (2013)
  10. Naghashpour M1, et al Riboflavin Supplementation to Patients with Multiple Sclerosis does not Improve Disability Status nor is Riboflavin Supplementation Correlated to Homocysteine . Int J Vitam Nutr Res. (2013)
  11. McKinley MC1, et al Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status . Eur J Clin Nutr. (2002)
  12. MacLennan SC1, et al High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial . J Child Neurol. (2008)
  13. Di Lorenzo C1, et al Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs . Neurology. (2009)
  14. Bruijn J1, et al Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial . Cephalalgia. (2010)
  15. Tavares NR1, Moreira PA, Amaral TF Riboflavin supplementation and biomarkers of cardiovascular disease in the elderly . J Nutr Health Aging. (2009)

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