This page on HbA1c is currently marked as in-progress. We are still compiling research.
You can help contribute by:
Scientific Information on HbA1c
Looking to buy Arginine? Buy from Amazon.com
Follow this Page for updates
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect HbA1c
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Supplement||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
Although the majority of evidence suggests absolutely no influence on HbA1c, reductions have been reported and a lone case has noted a clinically irrelevant increase of... show
There may be an effect on HbA1c, but it appears unreliable and not overly potent.
The reduction of HbA1c associated with berberine, according to a meta-analysis of diabetics using 1,000-1,500mg berberine daily, was −0.72% (95% CI −0.97 to −0.47)... show
Reduction seen in HbA1c was not overly remarkable
|B||Conjugated Linoleic Acid|
No significant reduction (or increase) in HbA1c levels following CLA supplementation
More evidence than not suggest no significant effect on HbA1c levels, but one study suggests a decent decrease with the other two studies trending towards a decrease. There... show
There appears to be a slight reducing effect on HbA1c
The decrease in HbA1c is statistically insignificant and very small in magnitude, likely not a concern.
No significant influence of Vitamin C supplementation on HbA1c levels
A possible reduction in HbA1c, but small in magnitude and unreliably seen
Lone study noted a decrease from 9% to 8% with 2g spirulina, which is somewhat notable but requires more evidence to establish this.
Preliminary evidence in diabetics suggest potent HbA1c reducing effects (6g of the root reducing HbA1c by 2% over a few months)
Two studies in diabetics have failed to find an influence of benfotiamine on HbA1c
|C||Olive leaf extract|
A minor decrease in HbA1c has been noted with olive leaf consumption
No significant influence on HbA1c serum levels has been detected
A decrease in HbA1c has been noted in diabetics given a tea of Salacia for months, but the decrease was minor in magnitude and outperformed by Glibenclamide
No significant alterations in HbA1c levels following Royal Jelly ingestion for 6 months
Requires more studies before conclusions can be made, appears to simply be exerting anti-oxidant effects.
A decrease in HbA1c levels has been detected in type II diabetics consuming Mate tea, although not to a remarkable degree
No significant influence of sulbutiamine on HbA1c
No significant influence on HbA1c levels of diabetics given chia seeds
A decrease in HbA1c has been noted with vanadium supplementation
|D||Tetradecyl Thioacetic Acid|
No significant alterations in HbA1c concentrations
A slight decrease in HbA1c has been noted with safflower despite no alterations in any other diabetic biomarker