Adiponectin is an adipokine (signalling molecule secreted from fat cells, like leptin) which positively influences glucose metabolism and fat loss. Increasing adiponectin levels are thought to result in fat loss and improved health.

This page features 18 unique references to scientific papers.

MUST GET: Supplement Stack Guides - Saving You Money & Time

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Adiponectin
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
B Conjugated Linoleic Acid
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Vitamin B3
C Arginine
C Curcumin
C Garlic
C Green Tea Catechins
C Inositol
C Irvingia gabonensis
C L-Carnitine
C Melatonin
C Astaxanthin
C Chromium
C Cocoa Extract
C Coenzyme Q10
C Fish Oil
C Licorice
C Nigella sativa
C Rose Hip
C Trimethylglycine
C Vitamin K
D Coffee
D Blueberry


  1. Blankenhorn DH1, et al Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound . Circulation. (1993)
  2. Cashin-Hemphill L1, et al Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up . JAMA. (1990)
  3. Blankenhorn DH, et al Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts . JAMA. (1987)
  4. Plaisance EP1, et al Increased total and high-molecular weight adiponectin after extended-release niacin . Metabolism. (2008)
  5. Bissett DL1, Oblong JE, Berge CA Niacinamide: A B vitamin that improves aging facial skin appearance . Dermatol Surg. (2005)
  6. Hakozaki T1, et al The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer . Br J Dermatol. (2002)
  7. AIM-HIGH Investigators, et al Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy . N Engl J Med. (2011)
  8. Fabbrini E1, et al Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease . J Clin Endocrinol Metab. (2010)
  9. Chen X1, Iqbal N, Boden G The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects . J Clin Invest. (1999)
  10. Chang AM1, et al Impaired beta-cell function in human aging: response to nicotinic acid-induced insulin resistance . J Clin Endocrinol Metab. (2006)
  11. No authors listed Clofibrate and niacin in coronary heart disease . JAMA. (1975)
  12. Gebicki J1, et al 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin . Pol J Pharmacol. (2003)
  13. Westphal S1, et al Extended-release niacin raises adiponectin and leptin . Atherosclerosis. (2007)
  14. Blond E1, et al Nicotinic acid effects on insulin sensitivity and hepatic lipid metabolism: an in vivo to in vitro study . Horm Metab Res. (2014)
  15. Kelly JJ1, et al Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects . J Hum Hypertens. (2000)
  16. Nasser Figueiredo V1, et al Short-term effects of extended-release niacin with and without the addition of laropiprant on endothelial function in individuals with low HDL-C: a randomized, controlled crossover trial . Clin Ther. (2014)
  17. Sakai T1, Kamanna VS, Kashyap ML Niacin, but not gemfibrozil, selectively increases LP-AI, a cardioprotective subfraction of HDL, in patients with low HDL cholesterol . Arterioscler Thromb Vasc Biol. (2001)
  18. Fraterrigo G1, et al Relationship between Changes in Plasma Adiponectin Concentration and Insulin Sensitivity after Niacin Therapy . Cardiorenal Med. (2012)

(Users who contributed to this page include )