Memory

The ability to remember things currently being done (working memory) recently learned (short term) and possible for life (long term memory); some compounds enhance memory by reversing states of neural malaise (Fish Oil, Curcumin) whereas some can increase memory unilaterally (Bacopa Monnieri)

   
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Memory
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
SupplementChange
Magnitude of Effect Size
Scientific ConsensusComments
BBacopa Monnieri

Notable

Although general and requiring a long time to take effect (4-6 weeks), bacopa appears to reliably and effectively improve memory in both healthy persons and during cognitive... show

BCaffeine

Overall, highly mixed effects effects of caffeine on memory. It appears to increase spatial/perceptual memory and reduce working memory (perhaps secondary to overstimulation)

BMelissa officinalis

Minor

Mixed influences on memory, with one study noting a decrease in 'total' memory formation and two studies noting improvements in 'quality' of memories formed. There is likely... show

CNicotine

Minor

An increase in memory has been noted with ingestion of nicotine in persons with mild cognitive impairment

CFish Oil

Minor

Possible improvements in memory

CS-Adenosyl Methionine

Minor

In persons with SSRIs, adding SAMe confers a cognitive promoting effect; it is unsure if this persists in persons without SSRIs, and this augmenting effect with SSRIs is... show

CPiracetam

Minor

Small increase in backwards recall with piracetam; nothing remarkable and overall very limited evidence in otherwise healthy individuals to draw from.

CGinger

Minor

An increase in memory has been noted in older women, no current studies in youth

CBlack Cohosh

No significant effect on memory function

CMelatonin

Minor

An increase in memory retention under periods of stress has been noted

CVinpocetine

Minor

An increase in acute memory formation has been noted in female volutneers given 40mg Vinpocetine

CCholine

No acute effect on spatial memory formation

CPhosphatidylserine

Minor

Increases in memory have been noted in persons with cognitive decline. A memory improving effect in otherwise healthy people is theoretical (secondary to reducing stress,... show

References

  1. Hirayama S, et al. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. (2013)
  2. Parker AG, et al. The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise. J Int Soc Sports Nutr. (2011)
  3. Schreiber S, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci. (2000)
  4. Kato-Kataoka A, et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. (2010)
  5. Manor I, et al. The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension. Eur Psychiatry. (2012)
  6. Vakhapova V, et al. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord. (2010)
  7. Baumeister J, et al. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. (2008)
  8. Jorissen BL, et al. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci. (2001)
  9. Kingsley MI, et al. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc. (2006)
  10. Kingsley MI, et al. Phosphatidylserine supplementation and recovery following downhill running. Med Sci Sports Exerc. (2006)
  11. Engel RR, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol. (1992)
  12. Crook T, et al. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull. (1992)
  13. Monteleone P, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. (1992)

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