Depression

Depression is a cognitive state associated with hopelessness and apathy. Clinical depression is a realm for medical doctors to address, but subclinical ennui might be counteracted with some supplements. Consider physical exercise as well, it might help a little.

   
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Depression
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
SupplementChange
Magnitude of Effect Size
Scientific ConsensusComments
AFish Oil
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
ASaffron
BZinc
BInositol
BChromium
CCreatine
CDehydroepiandrosterone
CPanax ginseng
CNicotine
CS-Adenosyl Methionine
CVitex agnus castus
CBacopa monnieri
CRhodiola Rosea
CL-Tyrosine
CGanoderma lucidum
CKava
CMaca
CVitamin C
CNefiracetam
CAshwagandha
CGinkgo biloba
CYamabushitake
CCentella asiatica
CN-Acetylcysteine
CRed Clover Extract
CMarijuana
DHoly Basil
DMagnesium
DLavender
DRoyal Jelly
DUridine
DVitamin B12
DPhenylpiracetam
DCurcumin

References

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  4. Appendino G, et al. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med. (2011)
  5. Chainani-Wu N, et al. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. J Am Acad Dermatol. (2012)
  6. Pungcharoenkul K, Thongnopnua P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytother Res. (2011)
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  20. Khajehdehi P, et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol. (2011)
  21. Carroll RE, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila). (2011)
  22. He ZY, et al. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest. (2011)
  23. Shimouchi A, et al. Effect of dietary turmeric on breath hydrogen. Dig Dis Sci. (2009)
  24. Usharani P, et al. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. (2008)
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