Depression is a cognitive state associated with hopelessness and apathy. Clinical depression is a realm for medical doctors to address, but subclinical ennui might be counteracted with some supplements. Consider physical exercise as well, it might help a little.

This page features 1 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Depression
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Fish Oil
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
A Saffron
B Zinc
B Chromium
B Inositol
C Creatine
C Red Clover Extract
C Rhodiola Rosea
C S-Adenosyl Methionine
C Ashwagandha
C Bacopa monnieri
C Centella asiatica
C Ganoderma lucidum
C Kava
C Maca
C Panax ginseng
C Vitex agnus castus
C Yamabushitake
C Dehydroepiandrosterone
C Ginkgo biloba
C L-Tyrosine
C Marijuana
C N-Acetylcysteine
C Nefiracetam
C Nicotine
C Vitamin C
D Agmatine
D Curcumin
D Holy Basil
D Lavender
D Magnesium
D Phenylpiracetam
D Royal Jelly
D Uridine
D Vitamin B12


  1. Keynan O, et al Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial . Pain Med. (2010)

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