Cognitive state of displeasing worry or concern with the feeling that bad events may arise; an impairment to well being, many supplements are anxiolytics (things that reduce anxiety).

This page features 44 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Anxiety
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Kava
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Ashwagandha
B Inositol
B Theanine
C Lavender
C Red Clover Extract
C Bacopa monnieri
C Caffeine
C Centella asiatica
C D-Serine
C Fish Oil
C Ganoderma lucidum
C Ginkgo biloba
C Maca
C Melissa officinalis
C Nicotine
C Saffron
C Sceletium tortuosum
C Vitex agnus castus
C Yamabushitake
C Yohimbine
C Black Cohosh
C Melatonin
C N-Acetylcysteine
C Synephrine
C Valeriana officinalis
D Holy Basil
D Phenylpiracetam


  1. Seedat S, Stein DJ Inositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: an open trial . Int Clin Psychopharmacol. (1999)
  2. Colazingari S, et al The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial . Arch Gynecol Obstet. (2013)
  3. Minozzi M, Nordio M, Pajalich R The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients . Eur Rev Med Pharmacol Sci. (2013)
  4. Agostini R, Rossi F, Pajalich R Myoinositol/folic acid combination for the treatment of erectile dysfunction in type 2 diabetes men: a double-blind, randomized, placebo-controlled study . Eur Rev Med Pharmacol Sci. (2006)
  5. Benjamin J, et al Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder . J Psychiatr Res. (1997)
  6. Palatnik A, et al Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder . J Clin Psychopharmacol. (2001)
  7. Benjamin J, et al Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder . Am J Psychiatry. (1995)
  8. Fux M, et al Inositol treatment of obsessive-compulsive disorder . Am J Psychiatry. (1996)
  9. Chengappa KN, et al Inositol as an add-on treatment for bipolar depression . Bipolar Disord. (2000)
  10. Nierenberg AA, et al Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone . Am J Psychiatry. (2006)
  11. Levine J, et al Double-blind, controlled trial of inositol treatment of depression . Am J Psychiatry. (1995)
  12. Nordio M, Proietti E The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone . Eur Rev Med Pharmacol Sci. (2012)
  13. Donà G, et al Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome . Eur J Endocrinol. (2012)
  14. Gerli S, Mignosa M, Di Renzo GC Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial . Eur Rev Med Pharmacol Sci. (2003)
  15. Raffone E, Rizzo P, Benedetto V Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women . Gynecol Endocrinol. (2010)
  16. Costantino D, et al Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial . Eur Rev Med Pharmacol Sci. (2009)
  17. Genazzani AD, et al Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients . Gynecol Endocrinol. (2012)
  18. Lisi F, et al Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study . Reprod Biol Endocrinol. (2012)
  19. Genazzani AD, et al Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome . Gynecol Endocrinol. (2008)
  20. Papaleo E, et al Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction . Gynecol Endocrinol. (2007)
  21. Gerli S, et al Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS . Eur Rev Med Pharmacol Sci. (2007)
  22. D'Anna R, et al Myo-inositol may prevent gestational diabetes in PCOS women . Gynecol Endocrinol. (2012)
  23. Corrado F, et al The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes . Diabet Med. (2011)
  24. Ciotta L, et al Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial . Eur Rev Med Pharmacol Sci. (2011)
  25. Zacchè MM, et al Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome . Gynecol Endocrinol. (2009)
  26. Santamaria A, et al One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome . Climacteric. (2012)
  27. Unfer V, et al Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial . Eur Rev Med Pharmacol Sci. (2011)
  28. Minozzi M, D'Andrea G, Unfer V Treatment of hirsutism with myo-inositol: a prospective clinical study . Reprod Biomed Online. (2008)
  29. Iuorno MJ, et al Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome . Endocr Pract. (2002)
  30. Gianfranco C, et al Myo-inositol in the treatment of premenstrual dysphoric disorder . Hum Psychopharmacol. (2011)
  31. Salloway S, et al A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease . Neurology. (2011)
  32. Maeba R, et al Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome . J Nutr Sci Vitaminol (Tokyo). (2008)
  33. Papaleo E, et al Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial . Fertil Steril. (2009)
  34. Lam S, et al A phase I study of myo-inositol for lung cancer chemoprevention . Cancer Epidemiol Biomarkers Prev. (2006)
  35. Levine J, et al Lack of effect of inositol treatment in chronic schizophrenia . Biol Psychiatry. (1993)
  36. Levine J, et al Lack of effect of 6 g inositol treatment of post-ECT cognitive function in humans . J Psychiatr Res. (1995)
  37. Nemets B, et al Inositol addition does not improve depression in SSRI treatment failures . J Neural Transm. (1999)
  38. Levine J, et al CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia . Eur Neuropsychopharmacol. (1994)
  39. Gelber D, Levine J, Belmaker RH Effect of inositol on bulimia nervosa and binge eating . Int J Eat Disord. (2001)
  40. Nemets B, et al Myo-inositol has no beneficial effect on premenstrual dysphoric disorder . World J Biol Psychiatry. (2002)
  41. Levine J, et al Inositol treatment of autism . J Neural Transm. (1997)
  42. Kaplan Z, et al Inositol treatment of post-traumatic stress disorder . Anxiety. (1996)
  43. Barak Y, et al Inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial . Prog Neuropsychopharmacol Biol Psychiatry. (1996)
  44. Allan SJ, et al The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial . Br J Dermatol. (2004)

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