Cognitive state of displeasing worry or concern with the feeling that bad events may arise; an impairment to well being, many supplements are anxiolytics (things that reduce anxiety).

This page features 3 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Anxiety
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Kava
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Ashwagandha
B Inositol
B Theanine
C Lavender
C Red Clover Extract
C Bacopa monnieri
C Caffeine
C Centella asiatica
C D-Serine
C Fish Oil
C Ganoderma lucidum
C Ginkgo biloba
C Maca
C Melissa officinalis
C Nicotine
C Saffron
C Sceletium tortuosum
C Vitex agnus castus
C Yamabushitake
C Yohimbine
C Black Cohosh
C Melatonin
C N-Acetylcysteine
C Synephrine
C Valeriana officinalis
D Holy Basil
D Phenylpiracetam


  1. Chiu S1, et al Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer's Dementia . Evid Based Complement Alternat Med. (2014)
  2. Terburg D1, et al Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus . Neuropsychopharmacology. (2013)
  3. Nell H1, et al A randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adults . J Altern Complement Med. (2013)

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