Taurine

Taurine is not bull urine, it is an amino acid with a sulfur in it. It is found in foods, in highest amounts in meats, and is a heart and blood healthy agent that can confer a wide variety of health benefits. Its most well known usage is to reduce cramping caused by fat burners like Ephedrine.

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Taurine is a semi-essential amino acid which acts as a lipid/membrane stablilizer in the body and can aid various anti-oxidant defense systems.

Taurine exerts most of its benefits vicariously though other compounds in the body, but exerts some of its own on a cellular level. It is being heavily researched as an anti-diabetic compound due to its actions on organs of the body of most concern to diabetics (kidney, eye, nerve health) as well as controlling blood sugar while reducing some forms of insulin resistance.

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Also Known As

2-aminoethane sulphonic acid, L-Taurine


Do Not Confuse With

Tacrine


Things to Note

Taurine is slightly depressive via increasing GABA levels in the brain.

Dosages between 500mg-2,000mg have shown efficacy, although the upper limit for toxicity is placed at a much greater level and high doses are well-tolerated.

The upper limit for which one can be relatively assured no side effects will occur over a lifetime has been suggested to be 3g a day.


The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what effect Taurine has in your body, and how strong these effects are.
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
EffectChange
Magnitude of Effect Size
Scientific ConsensusComments
CBlood Pressure

Despite the improvement in blood flow, no significant influence on blood pressure

CHeart Rate

No significant influence on heart rate following Taurine supplementation

CBlood Flow

Notable

The improvement in blood flow seen in type 1 diabetics was sufficient to normalize to a non-diabetic control group

CMuscle Soreness
CMuscle Damage
CFat Oxidation
CRate of Perceived Exertion
CAnaerobic Running Capacity
DExercise Capacity (with Heart Conditions)

Minor

An improvement in walking distance has been noted

DWeight

No significant influence on weight noted with supplementation


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Table of Contents:


Edit1. Sources and Structure

1.1. Source

Taurine is a semi-essential amino acid (conditionally essential) that is known as a sulfur containing beta-amino acid due to its structure. It comprises over 50% of the free amino acid pool of cardiac tissue (highly prominent)[1][2] but is located systemically in lower concentrations, particularily the testicles where it is the most prominent free amino acid.[3][4] In general, taurine is present in excitable tissues more than others[5] although as its transporter is expressed ubiquitously it could be assumed taurine is omnipresent in the human body.[6]

Unlike other amino acids and more like beta-amino acids, taurine is not a structural component of any quaternary proteins or peptide bonds and resembles a peptide neurotransmitter (like adrenaline or dopamine) more than classical dietary proteins.[7]

1.2. Structure

Taurine is highly water soluble (10.48g/100mL)[8] and, structurally, is an amino group paired to a sulfonic group by two methylene groups in a chain. It is a beta-amino acid (similar to Beta-Alanine).

1.3. Biological Significance

Taurine maintains an intracellular concentration of 5-20 µmol/g wet weight,[9][10] and enters cells through its transporter, the Taurine Transporter (TauT) that belongs to the class of sodium-chloride dependent transporters (similar to Creatine) and is named SLC6a6; this transporter is expressed in most, if not all, mammalian tissue.[6] Pathological problems are observed when cellular taurine is depleted, and this is observed in as little as 48 hours when the transporter is either blocked by a competitive inhibitor[11] or outright deleted.[12] The reasons for this depletion is that intracellular (within the cell) synthesis of taurine is limited, and cells appear to be dependent on taurine uptake from the blood, and the average serum concentration appears to be 20-100uM (up to 100 fold less than cells), which is reason for the active transport via TauT as taurine uptake works againt a concentration gradient.[12]

Cellular accumulation of Taurine is dependent almost exlusively on the SLC6a6 transporter, and avoiding pathological conditions of Taurine deficiency are dependent on having taurine in the cell

1.4. Taurine Deficiency

In non-human species who cannot synthesize taurine, it is an essential nutrient. The primary example of a species that is taurine-dependent is all feline species (cat family) where a lack of dietary taurine results in cardiopathology, impaired muscular function, and ocular degeneration.[13][14] These side-effects may occur to humans if a taurine deficiency exists, but this assumes an error in inborn metabolism impairing one's ability to synthesis taurine. The average human would not need to worry about outright taurine deficiency and its clinical manifestations.

Cats need taurine like a vitamin, these same deficiency conditions may exist with humans but since we synthesize taurine we are not outright dependent on it. Thus its status as 'conditionally essential'

It is possible to be 'deficiency' in taurine despite it being classified as a non-essential amino acid, and deficiency states can be induced experimentally with overfeeding of Beta-Alanine which competes at the level of the transporter due to being structured similarily.[1] Guanidinoethane sulfonate (GES) may also be used to inhibit taurine uptake.[15]

Knocking out the taurine transporter (TauT, also known as SLC6a6) genetically, and preventing its uptake into cardiomyocytes and skeletal muscle, can lead to cardiomyopathy and reduction in exercise performance coupled with a loss of body weight.[12]

Taurine deficiency in skeletal muscle is a bit difficult to assess as the two ways to inhibit uptake influence muscle function, as guanidinoethane sulfonate itself enhances response to Ca2+ in muscle cells[16] as does Beta-Alanine which is a proven ergogenic aid. Studies using genetic knock-out mice without the transporter at all note that weight-loaded swimming test performance was reduced from 118+/-2.3m to 10+/-2.5min,[17] treadmill running endurance is reduced by over 80%,[18] and the skeletal muscle itself undergoes atrophy with some cells actually displaying necrosis.[12]


Edit2. Pharmacology

2.1. Absorption

In the stomach, taurine seems to be safe from stomach acid and does not undergo changes.[19]

Taurine does not appear to undergo any changes in the environment of the stomach

In the intestines, pancreatin can reduce levels of detectable food-bound taurine by almost 40%.[19] However, this study noted that the taurine was not broken into metabolites but somehow became 'inaccessible', which may be due to the taurine being from meat.[19]

It has been hypothesized that taurine may enhance the absorption of lipid-soluble components,[20] based on its ability to conjugate with bile acids to promote water solubility secondary to formation of taurocholic acid (as seen with Tauroursodeoxycholic Acid[2] and in the general process of aiding phospholipid absorption from the intestines to the liver[21]) and its ability to enhance the water solublility of retinal (an aldehyde of vitamin A) which is also fat soluble as well as endogenously occurring.[22][23]


Edit3. Neurology

3.1. Regulation and Transport

Taurine has been noted to be taken up into synaptosomes via a high-affinity uptake system.[24]

3.2. Glutaminergic Neurotransmission

Taurine has been noted to potentiate signalling via presynaptic NMDA receptors (EC50 19µM) in a manner that is blocked by coadministration with Glycine.[25] Presynaptic NMDA receptors are those located prior to the synapse[26][27] and appear to promote release of glutamate[28][29] and GABA[30] into the synapse, they also require an agonist at the glycine binding site to work.[25]

Taurine has been found to not significantly alter fEPSPs in postsynaptic neurons (via NMDA) in one study[25] although others contrast this.[31] Taurine has been found to interact with the postsynaptic receptor at 100µM[32] and it appears to work via hindering how much agonists at the polyamine binding site (ie. spermidine) can increase affinity at the MK-801 binding site.[32]

Taurine has also been noted to diminish the affinity of glycine to the NMDA receptor.[32]

Taurine may be an indirect suppressor of NMDA signalling, and while it can also stimulate both glutamate and GABA release from the synapse it ultimately seems to reduce excitatory transmission

The suppressive effect of taurine on glutaminergic signalling seen with the NDMA receptors does not appear to extend to the kainate nor AMPA receptors.[32]

AMPA and Kainate are not known to be highly affected by taurine

Glutamic acid decarboxylase (GAD65 and GAD67) appears unaffected by chronic taurine intake at doses that are neuroactive.[33][34]

3.3. GABAergic Neurotransmission

Taurine is one of the major inhibitory amino acid neurotransmitters in the brain, alongside GABA and Glycine,[35][36] and while the latter two amino acids have their own signalling systems (GABAergic and Glycinergic) taurine is thought to act vicariously as a neuromodulator of these two systems.[37]

Taurine is known to bind to both GABAA[38] and GABAB[39] receptors

At 1µM, taurine is able to enhance NMDA-dependent phosphatidylinositol hydrolysis by 80.4+/-3.5%, which is due to its actions at the GABAB receptors.[40]

GABA transaminase (the enzyme that degrades GABA[41]) is not affected by taurine.[24]

Taurine is unable to prevent picrotoxin-induced seizures (antagonizing GABA receptors[42]).[8]

3.4. Glycinergic Neurotransmission

Taurine is able to act on Glycine receptors.

Glycinergic signalling mediates anxiolytic effects of taurine.[8]

3.5. Memory and Learning

Both Akt and GSK3β phosphorylation (the PI3K/Akt cascade) are enhanced in the hippocampus of rats fed around 230-460mg/kg daily for four weeks, while CAMKII phosphorylation was increased at only the higher dose and protein content itself was unaffected.[33][34]

3.6. Anxiety

200mg/kg taurine (but not 100mg/kg) given to mice 60 minutes before anxiety tests was able to reduce anxiety to a degree greater than the reference drug thiopental (25mg/kg) but lesser than midozolam (1.2mg/kg).[8] This anxiolytic effect was mediated by interactions with glycine receptors as they were abolished by antagonists of this receptor.[8]

Taurine has shown anti-anxiety actions following oral ingestion

3.7. Depression

Oral taurine (around 230-460mg/kg) has been noted to increase phosphorylation of ERK1, ERK2, and CREB in rats over four weeks without affecting protein content,[33][34] and this (MAPK)-CREB cascade is thought to play a role in depression.[43][44]

Taurine at 462.8+/-12.0mg/kg of the diet to rats over four weeks has shown antidepressant effects (reduced immobility in the forced swim test), while half this dose was ineffective.[33][34]


Edit4. Interactions with Cardiovascular Health

4.1. Mechanisms

Taurine acts as both a cell protecting agent by modulating the cell membranes fluidity and health, as well as exerting anti-oxidant like effects.

It may exert anti-oxidant like effects by binding free ions (Fe2+, Cu2+) and oxidant metalloproteins the blood[45] which would then act as pro-oxidants in situations of high blood glucose.[46] Taurine may also exert anti-oxidant like effects over time by preventing pro-oxidative effects associated with insulin resistance via it's insulin sensitizing actions.[47]

Taurine, at a concentration of 1mM, significantly reduces oxidative stress on cardiac muscle tissue in the presence of oxidative stress[48] and can protect against damage from ischaemia-reperfusion injury in cardiac tissue.[49]

4.2. Angiogenesis

Angiogenesis is the process of forming new blood vessels, and is of concern to both cardiovascular health (microcirculation) and cancer metabolism (fuelling tumor cells). Taurine appears to be able to activate angiogenesis (via Akt and via PI3K, FAK via Src, and ERK via MEK) and accelerate endothelial cell proliferation (via Cyclin D1/B), and angiogenesis appears to mediated from outside the cell as inhibiting taurine uptake with Beta-Alanine actually increased these effects.[50]

4.3. Interventions

One study on type I diabetic smokers with higher rates of endothelial dysfunction who were given taurine supplementation, 2 weeks of 1,500mg taurine supplementation was able to return these parameters to the levels of control and improve both blood flow (assessed by flow-mediated vasodilation and brachial flow).[51]


Edit5. Interactions with Glucose Metabolism

Many of the in vivo studies to follow were conducted in experimental procedures of fructose-induced insulin resistance.

Taurine may hold promise in treating insulin resistance by modifying the post-receptor (intracellular) effects of insulin signalling[52] as well as regenerating intrinsic antioxidants, reducing lipid peroxidation, and ameliorating insulin resistance in fructose-induced insulin resistance.[47] Taurine can also control glucose levels to a degree via improved acute insulin action.[53]

This anti-diabetic effect may be (in part) specific to fructose-induced insulin resistance (both hepatic and peripheral) due to the interactions with post-receptor intermediates (and subsequent receptor transcription) rather than receptor desensitization; as has been shown in fructose feedings.[54]

5.1. Diabetes

Outside of the previous benefits established in glucose metabolism, eye health, kidney health and endothelial health (all of which are systems that are potentially damaged in diabetics), taurine has other mechanisms which lead it to be a great conjunct treatment to diabetes management.

Taurine can aid in diabetic-induced joint pain by alleviating the glycation and physiological changes of collagen[55] via donating amino groups to glycating agents in a sacrificial manner[56] although the effect was only seen in those with compromised health. This is the same mechanism of actions seen to protect the retinas from glycation.


Edit6. Interactions with Physical Performance

6.1. Muscle Soreness

One study using 2,000mg taurine paired with 3,200mg BCAAs (to be taken thrice daily for two weeks prior to physical testing and four days after) noted that combination therapy, but neither placebo nor either supplement in isolation, was able to reduce muscle soreness.[57]

6.2. Aerobic Exercise

Fat oxidation during submaximal activity has been noted to be increased with an acute dose of 1,660mg taurine supplementation in trained cyclists, although this did not impact performance.[58]

Taurine at 1,000mg taken 2 hours prior to exercise has been implicated in improving performance on a 3km time trial in trained athletes, improving time by 1.7% without significantly affecting heart rate or oxygen uptake.[59] Trained cyclists given 1,660mg taurine an hour before cycling (nonmaximal cycling for 90 minutes followed by a time trial) failed to find an improvement in time trial performance with supplementation.[58]


Edit7. Interactions with Hormones

7.1. Testosterone

Taurine is investigated for its interactions with testosterone due to being the most prominent free amino acid localized in the testicles of males. It has been detected in Leydig cells, vascular endothelial cells, and other interstitial cells of testis, epithelial cells of the efferent ducts by immunohistochemical methods.[60] In the testes, taurine acts mostly as an anti-oxidant compound and protect the testes and localized structures from oxidative stress. This does appear to attenuate reductions of testosterone from other agents which may reduce testosterone via pro-oxidation, and this has been shown with Nicotine,[61] arsenic,[62] cadmium,[63] and doxorubicin.[64]

Another state in which taurine may prevent oxidation-mediated reductions in testosterone is diabetes. Excess glucose and pro-oxidants in the blood of diabetic rats negatively influence testicular function, which is attenuated by taurine[65] and testicular anti-oxidants in general.[66] One study to measure testicular anti-oxidant enzymes also found they were increased, with increases in superoxide dismutase (SOD) and glutathione with more efficacy in aged rats;[4] young rats had a remarkable increase in sorbitol dehydrogenase, and both groups experienced a slight increase in testicular Nitric Oxide levels.[4]

Maternal consumption of taurine also appears to beneficially influence androgen levels of the offspring, when measuring serum testosterone when the mother consumed 1% taurine in drinking water (rats).[4]

General protective effects of taurine on oxidant-induced decreases in testosterone, which is linked to taurine acting as an anti-oxidant and being highly concentrated in the testicles

One study in healthy 2-month old rats given 0.5, 1, and 1.5% taurine in the drinking water for 5 weeks noted increases in serum testosterone (as well as FSH and LH) with 1% being most significant and elevating testosterone in both serum and the testes from around 50ng/dL to 80ng/dL, a 60% increase.[67] These results were later replicated with 1% Taurine in the diet of adult and aged male rats, where an increase in testosterone and LH were noted in both groups but to a more significant degree in older rats.[4]

The mechanism, as assessed in vitro, appears to be enhancement of HCG-induced testosterone secretion at 10-100ug/mL (and also progresterone induced testosterone secretion) while 1ug/mL or less had no effect and 400ug/mL had a suppressive effect.[67] Secretion of testosterone was attenuated when cysteine sulfinate decarboxylase (CSD) was inhibited as well, suggesting that locally produced taurine also plays a role.[67]

The only human study on taurine (1500mg) was confounded with Creatine (5g) and Glucuronolactone (350mg) as well as Caffeine (110mg) and 19g Branched Chain Amino Acids (Amino Shooter, Champion Nutrition) and failed to show any significant influence on testosterone different than placebo.[68] The lack of response from creatine in increasing testosterone may be due to creatine's instability in solution, and the selected product being a ready-to-drink formulation (and thus no active creatine, only creatinine).[68]

Two studies have shown taurine supplementation to increase testosterone in otherwise healthy rats, no current human studies with similar design; one human study showing no effects of 1,500mg taurine acutely with other ingredient confounds

7.2. Estrogen

1% of the diet as taurine to adult or aged male rats does not appear to significantly influence estrogen levels.[4]


Edit8. Interaction with Oxidation

8.1. Mechanism

Taurine is an anti-oxidant compound with relatively unique mechanisms as it is directly unable to scavenge any free radical,[69] yet one of the events of taurine deficiency is tied into dysregulated oxidation.[70] One in vitro study noted that taurine deficiency (via Beta-Alanine incubation) was associated with increased oxidative stress (measured by aconitase and glutathione redox couplet) yet the 10% increase in taurine levels after incubation with taurine alone was not paired with any alteration and coincubation of the two also resulted in no significant differences with control cells (incubated with neither) and similar trends were seen in the mitochondria when measuring the activity of Complex I and III.[71] Beta-alanine resulted in an impaired electron-transport chain function (due to either beta-alanine per se or merely a deficiency of taurine), which tends to cause increases in superoxide production[72] due to spare electrons being diverted to other accepting molecules such as oxygen;[73] it appears that taurine prevents this increase in oxidation by attenuating its own deficiency at times.[71] These effects have been hypothesized elsewhere, and it was expanded that taurine may play a role in mitochondrial tRNA conjugation where its deficiency and the relative lack of conjugation produced oxidation via the aforementioned electron chain impairment.[74] This study hypothesized a lack of 5-taurinomethyluridine as the first step of mitochondrial impairment, but a later study failed to note this despite a decrease in mitochondrial protein synthesis.[11]

A cellular deficiency of taurine results in cellular death by pro-oxidative means, and indirectly dietary taurine can prevent oxidation by preventing its own deficiency

Taurine has also been found to upregulate thioredoxin interacting protein (TXNIP) mRNA levels, which is dependent on cellular accumulation of taurine.[75] As TXNIP regulates oxidation via thioredoxin, this is a plausible mechanism for anti-oxidative effects.


Edit9. Interactions with Organ Systems

9.1. Eyes

In cats and monkeys (known to be reliant on dietary taurine due to low endogenous synthesis), a deficiency of dietary taurine can result in significantly reduced taurine concentrations in the retina (up to a 50% reduction)[76] associated with retinal degeneration and impaired vision,[77][78][79] similar symptoms being shown in rats (adequate synthesis in the liver) treated with guanidinoethane sulfonate (transportation antagonist to taurine in the retina[80]) which has also resulted in retinal degeneration.[81]

On a mechanistic level, taurine is known to form conjugates with vitamin A (retinol) in the eye as a molecule known as all-trans retinylidene taurine or tauret. Tauret is synthesized within the retina[82] where it either plays a role in regenerating rhodopsin[83] and photoreceptors[84] (supported by channels into rods specialized for tauret[23]) or through binding to all-trans retinal (a prooxidant produced by light stimulation) and sequestering its prooxidative effects to a degree.

Taurine also exerts osmolytic properties in the retina[85] which may be mechanically protective of retinal rod outer segments by regulating hydration and pressure of these organelles.[86]

Taurine appears to have vital roles in the eyes for all tested mammalian species including primates. This protection and growth promoting properties seen with taurine are hypothesized to either be due to a stimulatory effect on photoreceptors and rhodopsin (a pigment vital for sight) or secondary to controlling prooxidative stressors within the eye that are a result of light stimulation

Taurine may also help protect the eyes from other stressors such as elevated glucose concentrations in retinal tissues[87][88] (a consequence of diabetes that may lead to diabetic retinopathy) and its efficacy in this model has been shown to be comparable to effective concentrations of the combination of Vitamin E and Selenium.[88]

The protective effects of taurine, at least in vitro, have been noted to extend towards elevated glucose concentrations in medium (a model for diabetic retinopathy)

9.2. Kidneys

Similar to the heart, taurine supplementation can protect against ischemia/reperfusion injury in the kidneys[89] and protect against toxin-induced oxidative stress[90][91] in addition to general diet-induced oxidative stress[92]

9.3. Lungs

Taurine may also protect the lungs from oxidant induced stress (as occurs with smoking) via acting in a sacrificial manner and producing N-chlorotaurine via reactions with hypochlorous acid (HOCl) rather than having HOCl react in alternate methods to induce inflammation responses which then cause damage.[93]

9.4. Liver

Taurine can protect the liver from acetominophen induced toxicity at a level slightly less potent than N-acetylglutathione.[94] It may also exert protective effects against other toxins in general.[95]


Edit10. Interactions with Aesthetics

10.1. Skin

In isolated skin cells treated with UV(A) radiation, whereas the cells normally take up a variety of osmolytes (Inositol and TMG as well) it is noted that all osmolytes are increased in their cellular uptake with taurine having a 69% increase (but TMG having the largest increase at 170%);[96] however, it seems that taurine exclusively was capable of suppressing the increase in IL-6 secreted from the radiation.[96]


Edit11. Safety and Toxicity

11.1. General

The observed safety limit, the highest dose for which one can be relatively assured that no side effects will occur over a lifetime, has been suggested to be 3g of taurine in supplemental form (in addition to food intake) a day.[97] Higher doses have been tested and well tolerated, but not enough evidence is available to suggest lifelong safety of said doses.

There is a notion that taurine causes heart damage, which is currently unsupported (and contrary to a fair bit of evidence). This appears to be due to a misunderstanding of why serum taurine levels are elevated during cardiac failure (which is from taurine leakage from cells).

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

References

  1. Pansani MC, et al. Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats. PLoS One. (2012)
  2. Jacobsen JG, Smith LH. Biochemistry and physiology of taurine and taurine derivatives. Physiol Rev. (1968)
  3. Higuchi M, et al. Taurine plays an important role in the protection of spermatogonia from oxidative stress. Amino Acids. (2012)
  4. Yang J, et al. Effects of taurine on male reproduction in rats of different ages. J Biomed Sci. (2010)
  5. Huxtable RJ. Physiological actions of taurine. Physiol Rev. (1992)
  6. Uchida S, et al. Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci U S A. (1992)
  7. Bouckenooghe T, Remacle C, Reusens B. Is taurine a functional nutrient. Curr Opin Clin Nutr Metab Care. (2006)
  8. Zhang CG, Kim SJ. Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Ann Nutr Metab. (2007)
  9. Chapman RA, Suleiman MS, Earm YE. Taurine and the heart. Cardiovasc Res. (1993)
  10. Chesney RW. Taurine: its biological role and clinical implications. Adv Pediatr. (1985)
  11. Jong CJ, et al. Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content. J Biomed Sci. (2010)
  12. Ito T, et al. Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice. J Biomed Sci. (2010)
  13. Sturman JA. Dietary taurine and feline reproduction and development. J Nutr. (1991)
  14. Pion PD, et al. Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science. (1987)
  15. Lake N. Loss of cardiac myofibrils: mechanism of contractile deficits induced by taurine deficiency. Am J Physiol. (1993)
  16. Cuisinier C, et al. Effects of guandinoethane sulfonate on contraction of skeletal muscle. Adv Exp Med Biol. (2000)
  17. Ito T, et al. Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol. (2008)
  18. Warskulat U, et al. Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J. (2004)
  19. Purchas RW, Busboom JR, Wilkinson BH. Changes in the forms of iron and in concentrations of taurine, carnosine, coenzyme Q(10), and creatine in beef longissimus muscle with cooking and simulated stomach and duodenal digestion. Meat Sci. (2006)
  20. Petrosian AM, Haroutounian JE. Taurine as a universal carrier of lipid soluble vitamins: a hypothesis. Amino Acids. (2000)
  21. Nakashima T, et al. Taurine in the liver. The function of taurine conjugated with bile acids. Adv Exp Med Biol. (1996)
  22. Study of taurine and tauret content in the compound eye of locust with light and dark adaptation
  23. Petrosian AM, Haroutounian JE, Zueva LV. Tauret. A taurine-related endogenous substance in the retina and its role in vision. Adv Exp Med Biol. (1996)
  24. Frosini M, et al. Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain. Br J Pharmacol. (2003)
  25. Suárez LM, Solís JM. Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons. Eur J Neurosci. (2006)
  26. Paquet M, et al. AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study. J Neurosci. (1997)
  27. Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus
  28. Mameli M, et al. Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. J Neurosci. (2005)
  29. Bardoni R, et al. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci. (2004)
  30. Fiszman ML, et al. NMDA receptors increase the size of GABAergic terminals and enhance GABA release. J Neurosci. (2005)
  31. Banerjee SP, et al. Neuropsychopharmacological actions of taurine. Adv Exp Med Biol. (2013)
  32. Chan CY, et al. Direct interaction of taurine with the NMDA glutamate receptor subtype via multiple mechanisms. Adv Exp Med Biol. (2013)
  33. Iio W, et al. The effects of oral taurine administration on behavior and hippocampal signal transduction in rats. Amino Acids. (2012)
  34. Toyoda A, Iio W. Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats. Adv Exp Med Biol. (2013)
  35. Yakimova K, et al. Effects of GABA agonists and antagonists on temperature-sensitive neurones in the rat hypothalamus. J Physiol. (1996)
  36. Barbeau A, et al. The neuropharmacology of taurine. Life Sci. (1975)
  37. Kuriyama K, Hashimoto T. Interrelationship between taurine and GABA. Adv Exp Med Biol. (1998)
  38. Bureau MH, Olsen RW. Taurine acts on a subclass of GABAA receptors in mammalian brain in vitro. Eur J Pharmacol. (1991)
  39. Kontro P, Oja SS. Interactions of taurine with GABAB binding sites in mouse brain. Neuropharmacology. (1990)
  40. Smith SS, Li J. GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum. Neurosci Lett. (1991)
  41. Sarup A, Larsson OM, Schousboe A. GABA transporters and GABA-transaminase as drug targets. Curr Drug Targets CNS Neurol Disord. (2003)
  42. Pericić D, Manev H, Bujas M. Gonadal hormones and picrotoxin-induced convulsions in male and female rats. Brain Res. (1996)
  43. New approaches to antidepressant drug discovery: beyond monoamines
  44. Iio W, et al. Effects of chronic social defeat stress on MAP kinase cascade. Neurosci Lett. (2011)
  45. Trachtman H, et al. Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy. Am J Physiol. (1992)
  46. Wu QD, et al. Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. Am J Physiol. (1999)
  47. Effects of Taurine on Biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats
  48. Hanna J, et al. Protective effect of taurine against free radicals damage in the rat myocardium. Exp Toxicol Pathol. (2004)
  49. Kingston R, Kelly CJ, Murray P. The therapeutic role of taurine in ischaemia-reperfusion injury. Curr Pharm Des. (2004)
  50. Baek YY, et al. Extracellular taurine induces angiogenesis by activating ERK-, Akt-, and FAK-dependent signal pathways. Eur J Pharmacol. (2012)
  51. Moloney MA, et al. Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res. (2010)
  52. Nandhini AT, Thirunavukkarasu V, Anuradha CV. Taurine modifies insulin signaling enzymes in the fructose-fed insulin resistant rats. Diabetes Metab. (2005)
  53. Nandhini AT, Anuradha CV. Taurine modulates kallikrein activity and glucose metabolism in insulin resistant rats. Amino Acids. (2002)
  54. Catena C, et al. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am J Hypertens. (2003)
  55. Taurine prevents collagen abnormalities in high-fructose fed rats
  56. Devamanoharan PS, Ali AH, Varma SD. Oxidative stress to rat lens in vitro: protection by taurine. Free Radic Res. (1998)
  57. Ra SG, et al. Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise. Adv Exp Med Biol. (2013)
  58. Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. (2010)
  59. Balshaw TG, et al. The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners. Amino Acids. (2012)
  60. Lobo MV, Alonso FJ, del Río RM. Immunohistochemical localization of taurine in the male reproductive organs of the rat. J Histochem Cytochem. (2000)
  61. Jana K, Samanta PK, De DK. Nicotine diminishes testicular gametogenesis, steroidogenesis, and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alteration of testicular antioxidant status. Toxicol Sci. (2010)
  62. Das J, et al. Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. (2009)
  63. Manna P, Sinha M, Sil PC. Cadmium induced testicular pathophysiology: prophylactic role of taurine. Reprod Toxicol. (2008)
  64. Das J, et al. Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis. Amino Acids. (2012)
  65. Shrilatha B, Muralidhara. Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. Reprod Toxicol. (2007)
  66. Tsounapi P, et al. Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Mol Cell Biochem. (2012)
  67. Yang J, et al. CSD mRNA expression in rat testis and the effect of taurine on testosterone secretion. Amino Acids. (2010)
  68. Ratamess NA, et al. Effects of an amino acid/creatine energy supplement on the acute hormonal response to resistance exercise. Int J Sport Nutr Exerc Metab. (2007)
  69. Aruoma OI, et al. The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J. (1988)
  70. Schaffer SW, et al. Physiological roles of taurine in heart and muscle. J Biomed Sci. (2010)
  71. Jong CJ, Azuma J, Schaffer S. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids. (2012)
  72. Ricci C, et al. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. Am J Physiol Cell Physiol. (2008)
  73. Mitochondrial formation of reactive oxygen species
  74. Schaffer SW, Azuma J, Mozaffari M. Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol. (2009)
  75. Gondo Y, et al. Effect of taurine on mRNA expression of thioredoxin interacting protein in Caco-2 cells. Biochem Biophys Res Commun. (2012)
  76. Retinal morphology and visual pigment levels in 6-and 12-month-old rhesus monkeys fed a taurine-free human infant formula
  77. Retinal degeneration in primates raised on a synthetic human infant formula
  78. Schmidt SY, Berson EL, Hayes KC. Retinal degeneration in cats fed casein. I. Taurine deficiency. Invest Ophthalmol. (1976)
  79. Hayes KC, Carey RE, Schmidt SY. Retinal degeneration associated with taurine deficiency in the cat. Science. (1975)
  80. Quesada O, Huxtable RJ, Pasantes-Morales H. Effect of guanidinoethane sulfonate on taurine uptake by rat retina. J Neurosci Res. (1984)
  81. Pasantes-Morales H, et al. Effects of the taurine transport antagonist, guanidinoethane sulfonate, and beta-alanine on the morphology of rat retina. J Neurosci Res. (1983)
  82. Petrosian AM, et al. New HPLC evidence on endogenous tauret in retina and pigment epithelium. Adv Exp Med Biol. (2000)
  83. Petrosian AM, Poghosyan LA, Haroutounian JE. Study of taurine and tauret content in the compound eye of locust with light and dark adaptation. Amino Acids. (2006)
  84. Altshuler D, et al. Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development. (1993)
  85. Pasantes-Morales H, Morán J, Schousboe A. Taurine release associated to cell swelling in the nervous system. Prog Clin Biol Res. (1990)
  86. Petrosian AM, Haroutounian JE. The role of taurine in osmotic, mechanical, and chemical protection of the retinal rod outer segments. Adv Exp Med Biol. (1998)
  87. Son HY, Kim H, H Kwon Y. Taurine prevents oxidative damage of high glucose-induced cataractogenesis in isolated rat lenses. J Nutr Sci Vitaminol (Tokyo). (2007)
  88. Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations
  89. Guz G, et al. The effect of taurine on renal ischemia/reperfusion injury. Amino Acids. (2007)
  90. Tabassum H, et al. Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. Hum Exp Toxicol. (2007)
  91. Manna P, Sinha M, Sil PC. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids. (2009)
  92. Trachtman H, et al. Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol. (1995)
  93. Schuller-Levis G, et al. Taurine protects against oxidant-induced lung injury: possible mechanism(s) of action. Adv Exp Med Biol. (1994)
  94. Acharya M, Lau-Cam CA. Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J Biomed Sci. (2010)
  95. Sinha M, Manna P, Sil PC. Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes. Toxicol In Vitro. (2007)
  96. Warskulat U, et al. Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts. Exp Dermatol. (2008)
  97. Shao A, Hathcock JN. Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul Toxicol Pharmacol. (2008)
  98. Beyranvand MR, et al. Effect of taurine supplementation on exercise capacity of patients with heart failure. J Cardiol. (2011)

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