The main component, Ephedrine, is the main active ingredient for weight loss and the caffeine augments its efficacy. The aspirin is added to prevent blood clotting (which may be a side effect of ephedrine) and to aid in the signal transduction of ephedrine via prostaglandin inhibition.
Some proponents of the ECA stack recommend replacing the Aspirin in the stack with either Fish Oil or White willow bark, as Aspirin is linked to various organ side effects and the previous two compounds share the same anti-clotting mechanisms.
Studies have shown that the combination of Ephedrine and Caffeine is superior for fat loss than taking each individually. As ephedrine can increase heart rate and caffeine may increase blood pressure (in a naive user), the combination tends to have an additive rather than synergistic toxicological profile.
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Ephedrine/Caffeine/Aspirin, ECA Stack, EC Stack
The ECA stack is a classical example of combining synergistic stimulants, and thus should be proceeded with caution in somebody not used to either stimulant in these doses.Examine.com Medical Disclaimer
ECA itself, Ephedrine with Caffeine and Aspirin, has been shown numerous times to be safe and well tolerated although the amount of studies on the subject matter pale in comparison to just EC (Ephedrine and Caffeine).
Actually significant side effects come with either dose abuse (OD-ing on the stuff) or when the ECA is taken vicariously through herbs, like a combination of Ma Huang, Kola Nut, and White Willow Bark (sources of E, C, and A; respectively)
Compounds that can further augment an ECA stacks effectiveness, like Green Tea Catechins or Yohimbine, should be approached cautiously. They can be quite potent, but at the same time can open up one to more side-effects.
Combine it with a good hypocaloric diet and exercise, and perhaps you'll lose 66kg over 13 months like this guy
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what effect ECA has in your body, and how strong these effects are.
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Effect||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
At least in persons with upper respiratory tract infections, a possible analgesic effect of ephedrine with aspirin exists
Due to the ephedrine component, ECA may also reduce nasal congestion
See 2 studies
The increase in metabolic rate seen with ephedrine is augmented with the inclusion of both aspirin and caffeine, hence its notable efficacy
Due to both the increase in metabolic rate and reduction in appetite reported, there are notable weight reductions with the ECA stack
No significant alterations in long term blood pressure, although acute spikes are possible due to the ephedrine and caffeine components
Heart rate at rest is not affected by ECA supplementation and may indirectly be lowered secondary to weight loss. However, an acute increase in heart rate is possible from... show
No significant alterations in blood glucose noted with ECA supplementation
No significant alterations in fasting insulin reported
No significant influence on total cholesterol levels
Three doses of:
The ECA stack is usually taken in 6-8 week cycles. Dosages should start off small, before reaching 3 doses a day.
(Common misspellings for ECA include EAC, EC)
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