Wrinkles
Summary of Wrinkles
Primary Information, Benefits, Effects, and Important Facts
Scientific Information on Wrinkles
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect wrinkles.
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Supplement |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
|---|---|---|---|---|
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Notable
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Very High See all 3 studies |
The appearance of fine (small) wrinkles appears to be reliably reduced with topical application of a nightly vitamin A cream, with efficacy in all ages assuming fine wrinkles are present.
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Minor
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- See study |
Topical application of nicotinamide appears to slightly reduce the appearance of fine wrinkles (crow's feet).
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Minor
|
- See study |
There appears to be a slight decrease in skin wrinkling following topical application of 0.3% ginkgo for 28 days
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