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Wrinkles

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Summary of Wrinkles

Scientific Information on Wrinkles

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Wrinkles.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 3 studies
The appearance of fine (small) wrinkles appears to be reliably reduced with topical application of a nightly vitamin A cream, with efficacy in all ages assuming fine wrinkles are present.
grade-c Minor - See study
Topical application of nicotinamide appears to slightly reduce the appearance of fine wrinkles (crow's feet).
grade-d Minor - See study
There appears to be a slight decrease in skin wrinkling following topical application of 0.3% ginkgo for 28 days

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