Wrinkles Research Analysis

Summary of Wrinkles

Scientific Information on Wrinkles

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect wrinkles

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Vitamin A	Notable	Very High See all 3 studies	The appearance of fine (small) wrinkles appears to be reliably reduced with topical application of a nightly vitamin A cream, with efficacy in all ages assuming fine wrinkles are present.
Vitamin B3 (Niacin)	Minor	- See study	Topical application of nicotinamide appears to slightly reduce the appearance of fine wrinkles (crow's feet).
Ginkgo biloba	Minor	- See study	There appears to be a slight decrease in skin wrinkling following topical application of 0.3% ginkgo for 28 days
Moringa oleifera	Minor	- See study	Application of a 3% moringa leaf cream for three winter months in young adult males appeared to reduce visual wrinkles on the cheeks relative to control cream.
Rose Hip

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.