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Weight Loss

Our evidence-based analysis on weight loss features 333 unique references to scientific papers.

Research analysis led by .
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Summary of Weight Loss

Scientific Information on Weight Loss

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix looks at human studies to tell you what supplements affect Weight Loss.

Full details on all Weight Loss supplements are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
The weight loss that occurs during prolonged strenuous exercise (in these examples, skiing) are attenuated with BCAA supplementation relative to carbohydrate. This is likely indicative of lean mass and/or hydration, and is not necessarily an anti-fat loss effect
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Frequently Asked Questions and Articles on Weight Loss

5 little-known facts about protein
Can you survive if you eat only protein? Can you survive without eating protein? How does your body keep functioning when you fast? Do high-protein diets actually promote weight loss, or do they only help you retain muscle when you eat below maintenance? Find the answers to those questions, and more, in the article below.
Stepping up weight loss: Can walking help dieters shed fat?
Walking doesn't do much for fat loss on its own. But there's reason to suspect it could boost the benefits of a caloric deficit.
Will eating breakfast keep you lean?
A lot of the evidence supporting the idea that eating breakfast is important for shedding pounds comes from observational studies. Do clinical trials support this claim, too?
Exploring chia seeds for weight loss
Oh no, another superfood fad! Not so fast. This six month trial put chia seeds to a rigorous test, looking for weight loss in patients with type 2 diabetes.
Measuring body fat percentage: It's an accuracy thing
Comparing DEXA versus Bod Pod for people with different BMI.
Whey vs soy protein: which is better when losing weight?
Whey protein stimulates muscle protein synthesis rates more than soy protein, but supplementing with ~25 grams per day of either has similar effects on body composition over two weeks of dieting.
How important is sleep?
Sleep is incredibly important, and can be considered crucial alongside diet and exercise. Proper sleep habits help sustain many biological processes, and bad sleep can cause these processes to be suboptimal or even malfunction.
How to minimize fat gain during the holidays
Holiday season is when most people gain weight (and then struggle to take it off). Overfeeding on protein could be your solution in helping minimize the fat gain.
3 Science-based steps to curbing your appetite
Fiber, stress relief, and supplement options can help curb your appetite!
Can food have negative calories?
‘Negative calorie’ foods (foods that have fewer calories than your body expends to digest them) likely don't exist. However, food typically thought of as ‘negative calorie’ are often low in total calories and high in fiber and water content — so their regular consumption may aid in weight loss.
Can you lose weight by turning down the heater?
Does daily weighing help you lose weight?
Is it really that bad to skip breakfast?
The lowdown on intermittent fasting
We analyze the research on intermittent fasting and how it impacts your health.
Is my “slow metabolism” stalling my weight loss?
Does high-protein intake help when dieting?
We analyze a study which suggests that a higher protein-intake while dieting can help you lose more fat.
I'm not too tired to stuff my face
This study found that total sleep deprivation leads to more calories eaten overall, but those calories were all consumed at night. Sleep deprivation did not affect the amount of calories consumed the following day.
Low-fat vs. low-carb? Major study concludes: it doesn’t matter for weight loss
A year-long randomized clinical trial (DIETFITS) has found that a low-fat diet and a low-carb diet produced similar weight loss and improvements in metabolic health markers. Furthermore, insulin production and tested genes had no impact on predicting weight loss success or failure. Thus, evidence to date indicates you should choose your diet based on personal preferences, health goals, and sustainability.
Do you need to detox?
While your body does accumulate toxicants, cleanses (detox diets) aren’t supported by toxicological mechanisms or trial evidence, and they can occasionally be dangerous. Your liver, lungs, kidneys, and other organs work nonstop to “detoxify” you; a diet rich in protein, vegetables, and fruits will provide them with the nutrients they need to function optimally.
What should you eat for weight loss?
When it comes to figuring out what to eat for weight loss, the most important factor is eating less. When you consume less calories than you spend you will lose weight and the diet that helps you lose weight best will be the one that allows you to consume less calories without causing much distress or lethargy. The key is to pick a diet that you can adhere to.
How does protein affect weight loss?
When the goal is to intentionally lose weight, eating more protein can help both reduce body fat and maintain lean mass. The amount of protein tends to be more imporant than the source.
How do I get a six-pack?
You eat less food to reduce body fat. There will be abdominal muscles under the fat, and adding some muscle to this area (resistance training) can make them appear more aesthetic; fat loss is the main predictor, however
Does diet soda inhibit fat loss?
It does not inhibit fat loss at all, and may actually suppress appetite that could help fat loss (although it does not induce fat loss per se either). Diet soda, in regards to body fat, is a carbonated inert beverage
Does eating at night make it more likely to gain weight?
While the evidence is mixed, depending on who was studied and what the diets were, there does not seem to be a major inherent weight-gain effect when eating late at night. Individual results may vary, and other factors such as circadian rhythms should be considered as well.
How do I stay out of "starvation mode?"
Marasmus is a disease of caloric restriction, but you most likely don't have it. Your metabolic rate can definitely slow down during weight loss, but it will never slow to the point where it causes you to gain weight; in this sense, starvation mode is a myth.
Can hypothyroidism lead to fat gain?
Yes, a less active thyroid will reduce metabolic rate and can cause some weight gain. It is not a lot of weight gain though, and a subactive thyroid is not an excuse for obesity (if hypothyroidic, please see a doctor for medication; it burns fat)
Does aspartame increase appetite?
How do I lose fat around my belly?
I have lost significant weight and now have loose skin. How can I tighten up my skin?
Will lifting weights convert my fat into muscle?
Will my breasts shrink with weight loss?
Click here to see all 333 references.