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Total Cholesterol

Total Cholesterol is a phrase used to refer to all circulating cholesterol molecules, and is totalled by adding LDL-C, HDL-C and vLDL-C together. It is distinct from Triglycerides.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect total cholesterol
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 17 studies
Garlic supplementation or the raw garlic bulb appears to reduce cholesterol (total cholesterol, mostly due to LDL reductions) reliably and in the range of 10-15%
grade-a Minor Moderate See all 12 studies
There may be some limited efficacy of policosanol on cholesterol (when excluding the studies from cuba, which are highly suspicious, there is still some scattered but unreliable evidence) whereas it does not appear to be potent in any way.
grade-a - Very High See all 18 studies
Similar to its actions on LDL and HDL individually, chromium does not appear to have a significant role in improving total cholesterol levels in type II diabetic subjects.
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All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.