Symptoms of Schizophrenia
Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:
All content reviewed by the Examine.com Team. Published:
Last Updated:
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of schizophrenia
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
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Notable
|
High See all 4 studies |
While the magnitude of benefit seen with Sarcosine is comparable to both D-serine and glycine, it appears to require a much lower (more practical) dose than does glycine and is more reliable than D-serine
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Minor
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Moderate See all 6 studies |
D-Serine supplementation is able to reduce symptoms of schizophrenia (more efficacy on negative and cognitive symptoms rather than positive) in a dose-dependent manner between 30-120mg/kg, but possibly due to the unreliable increases in blood D-serine its benefits are also unreliable
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- | Very High See all 3 studies |
At the dose that showed anti-depressant effects, inositol failed to improve any symptoms associated with schizophrenia.
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