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Symptoms of Schizophrenia

Schizophrenia is a disorder with symptoms both positive (psychosis: hallucinations and delusions) and negative (depression and mild cognitive impairment).

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Last Updated:

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Symptoms of Schizophrenia.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable High See all 4 studies
While the magnitude of benefit seen with Sarcosine is comparable to both D-serine and glycine, it appears to require a much lower (more practical) dose than does glycine and is more reliable than D-serine
grade-b Minor Moderate See all 6 studies
D-Serine supplementation is able to reduce symptoms of schizophrenia (more efficacy on negative and cognitive symptoms rather than positive) in a dose-dependent manner between 30-120mg/kg, but possibly due to the unreliable increases in blood D-serine its benefits are also unreliable
grade-b - Very High See all 3 studies
At the dose that showed anti-depressant effects, inositol failed to improve any symptoms associated with schizophrenia.

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