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Symptoms of Schizophrenia

Schizophrenia is a disorder with positive (hallucinations and delusions) and negative (anhedonia and depression) symptoms alongside slight cognitive impairment, and some supplements are currently being investigated to aid in these symptoms.

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team.
Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of schizophrenia
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Sarcosine Notable High See all 4 studies
While the magnitude of benefit seen with Sarcosine is comparable to both D-serine and glycine, it appears to require a much lower (more practical) dose than does glycine and is more reliable than D-serine
grade-b D-Serine Minor Moderate See all 6 studies
D-Serine supplementation is able to reduce symptoms of schizophrenia (more efficacy on negative and cognitive symptoms rather than positive) in a dose-dependent manner between 30-120mg/kg, but possibly due to the unreliable increases in blood D-serine its benefits are also unreliable
grade-b Inositol - Very High See all 3 studies
At the dose that showed anti-depressant effects, inositol failed to improve any symptoms associated with schizophrenia.
grade-c Ginkgo biloba Minor Moderate See all 4 studies
Symptoms of schizophrenia appear to be reduced with supplementation of ginkgo biloba (EGb-761 at 240-360mg daily), although all studies currently use ginkgo alongside standard antipsychotic therapy. It appears effective as an add-on
grade-c Glycine  
grade-c Theanine  
grade-c Chromium  
grade-d Folic Acid  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.