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Restless leg syndrome (RLS)

Restless leg syndrome (RLS) is characterized by uncomfortable sensations in the legs that are momentarily relieved upon movement. The sensations typically worsen at night when the legs are at rest, which is incredibly disruptive to sleep quality.

Our evidence-based analysis on restless leg syndrome (rls) features 14 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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  1. ^ Venkateshiah SB, Ioachimescu OC. Restless legs syndrome. Crit Care Clin. (2015)
  2. ^ Winkelman JW, Gagnon A, Clair AG. Sensory symptoms in restless legs syndrome: the enigma of pain. Sleep Med. (2013)
  3. ^ Ramar K, Olson EJ. Management of common sleep disorders. Am Fam Physician. (2013)
  4. ^ Berger K, et al. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. (2004)
  5. ^ Stefansson H, et al. A genetic risk factor for periodic limb movements in sleep. N Engl J Med. (2007)
  6. ^ Trotti LM, Bhadriraju S, Rye DB. An update on the pathophysiology and genetics of restless legs syndrome. Curr Neurol Neurosci Rep. (2008)
  7. ^ Rye DB. The Molecular Genetics of Restless Legs Syndrome. Sleep Med Clin. (2015)
  8. ^ Schormair B, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurol. (2017)
  9. ^ Hening W. The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Clin Neurophysiol. (2004)
  10. ^ Trenkwalder C, Paulus W. Why do restless legs occur at rest?--pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2). Clin Neurophysiol. (2004)
  11. ^ Peeraully T, Tan EK. Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence. Transl Neurodegener. (2012)
  12. ^ Aurora RN, et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep. (2012)
  13. ^ Scholz H, et al. Dopamine agonists for restless legs syndrome. Cochrane Database Syst Rev. (2011)
  14. ^ Michael H Silber, et al. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clin Proc. (2021)