Quick Navigation

Symptoms of Multiple Sclerosis

Multiple sclerosis is an autoimmune neurological disease characterized by the destruction of the myelin sheaths (nerve insulators) on neurons in the central nervous system. Its symptoms can vary, but eye pain, difficulty balancing, and numbness, tingling, and weakness in limbs are common. Attacks are “multiple” over time and/or location in the nervous system.

Our evidence-based analysis on symptoms of multiple sclerosis features 2 unique references to scientific papers.

Nick Milazzo
Research analysis led by and reviewed by the Examine team.
Last Updated:

Summary of Symptoms of Multiple Sclerosis

Symptoms

Symptoms can vary depending on the location of demyelination. Below is a list of typical sites for lesions to form and their associated symptoms:[1]

Optic nerve

  • Optic neuritis

  • Pain when moving the eye

  • Blurred vision

Cerebellum

  • Instability/dizziness

Spinal cord

  • Weakness in limbs

  • Numbness or tingling in limbs

  • Short electric shock–like sensations

  • Muscle spasticity

Brain stem

  • Blurred or double vision

Bowel/bladder

  • Constipation

  • Increased need to urinate or urge incontinence

  • Erectile dysfunction

Additionally, the diffuse damage in normal appearing white matter (NAWM) and normal appearing gray matter (NAGM) can lead to cognitive dysfunction, which may include issues with:

  • Short-term memory

  • Attention

  • Processing speed

  • Visuospatial skills

  • Executive function

Notably, intellectual function and language typically aren’t affected.[2]

Easily stay on top of the latest nutrition research

Become an Examine Member to get access to the latest research. Get 150+ studies summarized for you across 25 different categories every month.

Members also have access to the Examine Study Database of 400+ supplements and their effects on 600+ health outcomes, as well as in-depth research analyses. Understand the whole body of nutrition and supplement evidence at a glance.

Get instant access — start your free 14-day trial

Already a Member? Click here to log in.


Human Effect Matrix

Unlocked for Examine Members

Easily stay on top of the latest nutrition research

Become an Examine Member to get access to the latest research. Get 150+ studies summarized for you across 25 different categories every month.

Members also have access to the Examine Study Database of 400+ supplements and their effects on 600+ health outcomes, as well as in-depth research analyses. Understand the whole body of nutrition and supplement evidence at a glance.

Get instant access — start your free 14-day trial

Already a Member? Click here to log in.


The Human Effect Matrix looks at human studies to tell you what supplements affect Symptoms of Multiple Sclerosis.

Unlock the full Study Database with an Examine Membership. Get a 14-day free trial.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a
Cannabis
Minor Very High See all 20 studies
Oral cannabis extract appears to modestly reduce pain and bladder dysfunction, while Nabiximols doesn't appear to be effective. For spasticity symptoms, neither of these products shows a clinically significant effect on an objective rating scale, though participants report modest subjective improvements. The effects of cannabis on cognitive symptoms are unclear.
grade-c
L-Carnitine
Minor - See study
Some symptoms associated with multiple sclerosis are noted to be reduced with carnitine ingestion.
grade-c
Modafinil
Minor Very High See 2 studies
Memory impairment in multiple sclerosis may be attenuated with supplementation of modafinil (250mg armodafinil), although other cognitive impairments associated with MS do not appear significantly affected.

Become an Examine Member to unlock the full Study Database.

You can currently view 3 supplements as a non-member — becoming a Member will give you access to 8 total supplements on symptoms of multiple sclerosis.

Already a Member? Log in now to access.

grade-c
Vitamin D
 
grade-c
Ginkgo biloba
 
grade-c
Vitamin B2
 
grade-d
Vitamin A
 
grade-d
Coenzyme Q10
 

Stay on top of the latest research

To unlock the full archives of our Study Database and research analyses, become an Examine Member today.

Start your 14-day free trial

Click here to see all 2 references.

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 2 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of research information and references for Symptoms of Multiple Sclerosis.

Examine.com is intended to be used for educational and information purposes only. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com.

Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com.

Supplements

Articles

Health Topics

Membership Free Trial

Protein Intake Guide + Calculator

How to read a study

Company

Resources

Never miss an update!

Your email is safe with us. We don’t share personal data.

This website is certified by Health On the Net Foundation. Click to verify.