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Symptoms of Intermittent Claudication

Intermittent claudication is a disorder of blood flow that limits mobility, and some supplements that aid in blood flow are known to prolong walking time and quality of life in persons with this condition.

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of intermittent claudication.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Minor Very High See all 6 studies
There appears to be reduced symptoms of intermittent claudication with ginkgo supplementation, although it seems to vary significantly from one individual to another and despite some persons experiencing large benefit the overall 'net' benefit is relatively minor.
grade-b Notable Very High See all 3 studies
Symptoms of intermittent claudation are notably reduced with L-Carnitine supplementation (the rate of improvement over time, as assessed by walking distance, seems to be doubled; ie. from 40% to 60% or 60% to 90%) and associated with the Propinyl-L-Carnitine form (found in the supplement GPLC). The role of propinoic acid cannot be ruled out at this time, and studies have note used basic L-carnitine or ALCAR
grade-c Notable - See study
The reduction of claudication symptoms appears to be fairly potent with ALA supplementation, although there is not a large body of evidence overall.

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grade-c  
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