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Symptoms of Diabetic Neuropathy

Diabetic neuropathy is nerve pain associated with diabetes, and is commonly targeted to improve quality of life in diabetics.

Kamal Patel
Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of diabetic neuropathy
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b
Alpha-Lipoic Acid
Notable Very High See 2 studies
Not yet compared to reference drugs, but it has been subject to a meta-analysis and appears to be more effective than other options for reducing nerve pain associated with diabetes. The lack of a reference comparison and some evidence suggesting no effect prevent a strong rating.
grade-c
Magnesium
Minor - See study
A reduction in symptoms associated with diabetic neuropathy has been noted with magnesium supplementation
grade-d
Sulbutiamine
- - See study
Insufficient evidence to support a role in diabetic neuropathy associated with sulbutiamine supplementation

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