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Symptoms of Carpal Tunnel

Carpal tunnel syndrome (CTS) is caused by the compression of the median nerve in the wrist. The symptoms include numbness, tingling, or pain in specific parts of the hand.

Our evidence-based analysis on symptoms of carpal tunnel features 9 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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Summary of Symptoms of Carpal Tunnel

Carpal tunnel syndrome (CTS) is caused by the compression of the median nerve in the wrist. The symptoms include numbness, tingling, or pain in certain parts of the hand innervated by the median nerve, as shown in Figure 1. It affects around[1][2] 3-6% of people, and subjective symptoms are associated[3] with anxiety, depression, and lower quality of life. The major biomechanical risk factors[4] for developing CTS are repetitive motions and forceful motions of the hand, as well as the combination of these two movement patterns. Non-hand-related associations exist[5] as well, such as not exercising, poor overall physical health, and lack of job satisfaction. Other disease states, such as hypothyroidism and diabetes, are also associated[6] with CTS.

Compression of the median nerve may cause biochemical changes in the nerve that contribute to damage. Animal studies show that crushing[7] rat nerves increases oxidative stress levels. Furthermore, humans with CTS show higher levels of oxidative stress both in their hand tendon[8] and globally[9].

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Symptoms of Carpal Tunnel.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Minor - See study
A decrease in symptoms has been noted, but the study was not structurally a good one; requires replication
grade-d - - See study
No apparent effect in one study.

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Click here to see all 9 references.