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Stress

Stress (particularly distress) is excessive stimulation of the body's resources that eventually manifests negative symptoms such as fatigue or depression. Several supplements, such as adaptogens, are thought to reduce the development of stress.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Stress.

Full details on all Stress supplements are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Notable Very High See all 5 studies
Ashwagandha appears to significantly reduce the symptoms of stress and its comorbidities (fatigue, temporary cognitive impairment, etc.) as well as biomarkers such as cortisol.
grade-c Minor - See study
There appears to be stress reducing properties associated with supplementation of this herb at 1g daily, although they may be secondary to anxiety reduction.
grade-c Minor - See study
Supplementation of eurycoma in stressed persons appears to reduce subjective perceptions of stress.

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