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Serum Folate

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Summary of Serum Folate

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Serum Folate


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect serum folate
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Trimethylglycine - Very High See all 4 studies
Chronically there are no changes to serum folate due to the body normalizing folate levels, but acute supplementation can reduce folate concentrations in serum sharply for a short time.
grade-c Red Clover Extract - - See study
There do not appear to be any significant changes to circulating folate seen with supplementation of red clover extract.
grade-c Vitamin E - - See study
Serum folate does not appear to be modified with supplementation of vitamin E.

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.