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Serum Cobalamin

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

Summary of Serum Cobalamin

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Serum Cobalamin

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect serum cobalamin.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c - Moderate See all 3 studies
Mixed evidence as to whether B12 is influenced with supplementation of betaine, but the higher quality study appears to show no effect (since the other study noted a decline in B12 in placebo).
grade-c - - See study
Serum levels of cobalamin (vitamin B12) do not appear to be influenced with supplementation of vitamin E.