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Serum Bicarbonate

Serum bicarbonate is a way to indirectly measure the pH of the blood, as a higher bicarbonate concentration tends to reflect a more alkaline (buffered) pH. Bicarbonate is reliably increased in oral sodium bicarbonate.

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect serum bicarbonate.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Strong Very High See all 47 studies
For the purpose of increasing serum bicarbonate concentrations, orally ingested bicarbonate is the reference compound for it. The increases tend to be around a 30% increase form baseline values (as there is always a circulating bicarbonate concentration)