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Sedation

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Summary of Sedation

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Sedation


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect sedation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Modafinil Strong Very High See 2 studies
Modafinil (300mg) taken prior to sleep is as potent as 20mg D-amphetamine in reducing the need to sleep and improving cognitive performance during intentional sleep deprivation. Occasionally, this potency manifests itself as the 'side-effect' of insomnia in some persons who take it in the AM
grade-c Lavender Minor - See study
An increase in sedation has been noted with aromatherapy, but not with oral usage of lavender supplements
grade-c Valeriana officinalis Minor Very High See 2 studies
Doses above 750mg may be associated with the 'morning hangover' side effect (sleepiness upon waking) whereas lower doses of 400mg have not been associated with such.
grade-c Synephrine - - See study
grade-c Theanine  
grade-d Peppermint  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.