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Sedation

Research analysis led by .
Reviewed by
Examine.com Team
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Summary of Sedation

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Sedation

Introducing Evidence-based Keto: Your no-hype guide to the ketogenic diet

We've spent the past year analyzing the research on the keto diet, and have just released Evidence-based Keto.

Clocking in at over 200 pages with 500+ references, it's the unbiased guide you need to the ketogenic diet.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect sedation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Strong Very High See 2 studies
Modafinil (300mg) taken prior to sleep is as potent as 20mg D-amphetamine in reducing the need to sleep and improving cognitive performance during intentional sleep deprivation. Occasionally, this potency manifests itself as the 'side-effect' of insomnia in some persons who take it in the AM
grade-c Minor - See study
An increase in sedation has been noted with aromatherapy, but not with oral usage of lavender supplements
grade-c Minor Very High See 2 studies
Doses above 750mg may be associated with the 'morning hangover' side effect (sleepiness upon waking) whereas lower doses of 400mg have not been associated with such.

To view this information, please see the ​Examine.com membership.

The evidence for each separate supplement is still freely available ​here.

grade-c  
grade-c  
grade-d  

Everything you need to know about the keto diet

When we asked our users what they wanted us to cover, many of them mentioned the keto diet.

So we listened. We spent the year looking up the research on the ketogenic diet to help guide you in your journey.

With Evidence-based Keto, Examine.com gives you all the scientific research, but in understandable language with tons of informative infographics. No opinion, no bias, no conflict of interest.

If you’re interested in keto, this is a must-have unbiased source.