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Reddening of the Skin

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

Summary of Reddening of the Skin

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Reddening of the Skin

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect reddening of the skin.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor Very High See 2 studies
Topical application of nicotinamide and its analogues (not including niacin) appears to reduce reddening of the skin.
grade-c Minor Very High See 2 studies
It appears that for conditions with reddened skin (purpura or bags under the eyes) that vitamin K may have a role in removing the blood from the skin and reducing redness when 5% phylloquinone is applied to the skin. Mechanisms are not known, and study quality at the moment is lacklustre