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Plasma melatonin refers to serum concentrations of melatonin, which are quite significantly spiked following consumption of melatonin supplementation. Other stimuli, such as dark therapy, may encourage production of melatonin and increase serum levels.
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"Plasma Melatonin," Examine.com, published on 5 July 2013, last updated on 29 April 2017, https://examine.com/topics/plasma-melatonin/