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Plasma Melatonin

Plasma melatonin refers to serum concentrations of melatonin, which are quite significantly spiked following consumption of melatonin supplementation. Other stimuli, such as dark therapy, may encourage production of melatonin and increase serum levels.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect plasma melatonin.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Strong Very High See all 6 studies
Plasma melatonin is increased at both night and daylight following supplementation of melatonin. Although the degree of increase is a tad unreliable, it seems to always occur and to a fairly large magnitude
grade-c - - See study
Despite increased rates of melatonin elimination from the body (via urinartion), there does not appear to be a significant influence on plasma melatonin concentrations.