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Plasma Arginine

Plasma arginine refers to blood concentrations of arginine, and can be increased following oral ingestion of mixed protein meals or any amino acid in the urea cycle.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect plasma arginine
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor Very High See all 6 studies
Supplemental L-Arginine increases plasma L-Arginine. The spike in plasma L-arginine concentrations may be slightly more than that seen with L-citrulline, but the latter lasts longer and is thus more effective
grade-c Notable Very High See 2 studies
Citrulline can increase plasma arginine concentrations, and due to acting as a resevoir of arginine it is actually more effective overall at increasing plasma arginine than arginine itself (acute peaks are still observed to a higher level with arginine supplementation).