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Oxygenation Cost of Exercise

The oxygenation cost of exercise refers to how much oxygen is required to metabolize energy efficiently, and a reduction in this cost signifies more efficiency and improved physical performance. Improved oxygen efficiency tends to result from increasing nitric oxide.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect oxygenation cost of exercise
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Notable Very High See 2 studies
A notable reduction in the oxygenation cost of exercise associated with nitrate supplementation.
grade-c Minor Moderate See 2 studies
When nitric oxide is increased, the oxygenation cost of exercise appears to be decreased. This is unreliable with supplemental L-arginine as arginine is unreliable in increasing nitric oxide
grade-c Minor - See study
Effective, but to a small degree based on one trial.

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