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Summary of Osteocalcin

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Osteocalcin

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect osteocalcin
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Magnesium Minor Moderate See 2 studies
Possible but unreliable increases in osteocalcin
grade-c Red Clover Extract - - See study
Circulating osteocalcin does not appear to be influenced with supplementation of red clover extract.
grade-d Vitamin C - - See study
No notable change in response to surgery-induced cortisol increases.

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.