Quick Navigation

Muscle Creatine Content

“Muscle creatine content” refers the amount of creatine (phosphocreatine included) stored in muscle tissues. This content can be increased by some supplements, notably oral creatine.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

📝 Don't fall for outdated information: Get Examine Personalized and acquire the latest research on 400+ supplements and their effects on 600+ health outcomes.

Already a member? Click here to login.

Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix looks at human studies to tell you what supplements affect Muscle Creatine Content.

Full details on all Muscle Creatine Content supplements are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Strong Very High See all 18 studies
Creatine supplementation is the reference compound for increasing muscular creatine levels; there is variability in this increase, however, with some nonresponders.
grade-c - - See study
Betaine (2g) has failed to increase phosphocreatine levels in skeletal muscle and failed to augment the increase caused by 20g of creatine.
grade-d Minor - See study
Has been associated with augmenting creatine uptake into muscle cells acutely; long term influence unknown

Become an Examine Personalized member can access the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.

Becoming an Examine subscriber not only unlocks the Human Effect Matrix for supplements, but also all health topics on Examine.com. We neatly summarize all the latest research so you can make the best decisions for your health based on what's accurate and not out-dated information.

Plus, you get a monthly summary of the latest research in the health topics you care about.