Mood

These are supplements which may have effects on various mood states and their related consequences. These states include:

Depression: These are areas that relate directly to how positive or negative people are feeling, including happiness, pleasure, clinical depression, bipolar disorder, etc.

Anxiety: these are areas that relate directly nervousness and fear, including common stress, generalized anxiety disorder, and specific anxiety disorders such as obssessive-compulsive disorder.

Supplements that affect these areas may do so through directly or indirectly affecting the activity and signalling of neutrotransmitters, hormones and other signaling molecules, altering brain energetics, neurogenesis, synaptic plasticity, and more. They may do so through being neurotransmitters and hormones, affecting their synthesis, reuptake, and signaling, affecting inflammatory signalling, ion channel function, protecting neurons, and more.

These categories are highly related to other categories such as Sleep, Energy and Stimulation, and Cognitive Function and Brain Health, both as causes and consequences.

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect mood.

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Level of Evidence ? The amount of high quality evidence. The more evidence, the more we can trust the results.	Supplement	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
	Rhodiola Rosea	Minor	Very High See 2 studies	An improvement in one uncontrolled study in people experiencing burnout and an improvement in mood during exercise have been noted.
	Coenzyme Q10	-	- See study

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