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Mood

These are supplements which may affect anxiety, depression, and their subclinical and related conditions.

Our evidence-based analysis on mood features 82 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:
NOTE: We are updating our coronavirus (COVID-19) page with evidence as it comes in.

Summary of Mood

These are supplements which may have effects on various mood states and their related consequences. These states include:

Depression: These are areas that relate directly to how positive or negative people are feeling, including happiness, pleasure, clinical depression, bipolar disorder, etc.

Anxiety: these are areas that relate directly nervousness and fear, including common stress, generalized anxiety disorder, and specific anxiety disorders such as obssessive-compulsive disorder.

Supplements that affect these areas may do so through directly or indirectly affecting the activity and signalling of neutrotransmitters, hormones and other signaling molecules, altering brain energetics, neurogenesis, synaptic plasticity, and more. They may do so through being neurotransmitters and hormones, affecting their synthesis, reuptake, and signaling, affecting inflammatory signalling, ion channel function, protecting neurons, and more.

These categories are highly related to other categories such as Sleep, Energy and Stimulation, and Cognitive Function and Brain Health, both as causes and consequences.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect mood.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Minor Very High See 2 studies
An improvement in one uncontrolled study in people experiencing burnout and an improvement in mood during exercise have been noted.
grade-d - - See study

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By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.

Frequently Asked Questions and Articles on Mood

The myth of the sugar rush
Common sense and plausible mechanistic arguments suggest that carbohydrates can influence mood. But do they? And by how much?
5 nutrients that could lift your mood
Many foods can temporarily boost your mood simply because they’re delicious. But healthy foods also contain certain nutrients that may have a more direct and lasting effect on your well-being.
What is 'roid rage'?
Mostly a myth; testosterone (including injections) can increase impulsivity in some but this does not appear to be reliable (does not affect every person tested), impulsivity might lead to aggression but this is drawing at straws now with the connections
Click here to see all 82 references.