Microcirculation Research Analysis

Summary of Microcirculation

Scientific Information on Microcirculation

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect microcirculation

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Centella asiatica	Notable	Very High See all 8 studies	There appears to be a notable improvement in microcirculation associated with oral ingestion of centella asiatica in the treatment of chronic venous insufficiency; this may extend to otherwise healthy persons, albeit at a lesser magnitude
Ginkgo biloba	Minor	- See study	There is a small increase in microcirculation seen in elderly persons given ginkgo biloba, extending to both periphery and the liver. Benefits seem to be time dependent and greater at day 30 relative to day 10
Hesperidin	Minor	- See study	While hesperidin does not influence basal (fasting) microcirculation, there is an acute increase in circulation seen with supplementation of hesperidin at the time of peak blood concentrations.
Vitamin C	Minor	- See study	An increase in microcirculation has been noted secondary to increased blood flow, thought to be a general property of antioxidants

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.