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Markers of airway inflammation

Airway inflammation plays a major part in several diseases like asthma. Several biomarkers related to airway inflammation can play a role in both diagnosis and monitoring these diseases as well as investigating the impact of interventions on the disease process.

Our evidence-based analysis on markers of airway inflammation features 5 unique references to scientific papers.

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Summary of Markers of airway inflammation

Airway inflammation plays an integral role in diseases like asthma. Traditional lung function tests can measure severity, but don’t necessarily examine the underlying process of inflammation that strongly contributes to the disease. That’s where biomarkers can come in.[1] Measuring factors that are involved in the inflammation that causes the disease can help clinicians with diagnosis, tracking disease progress, and possibly optimizing therapy. Measuring markers of airway inflammation can also help scientists get a clearer view of how certain interventions could impact diseases like asthma.

Here are some key biomarkers of airway inflammation:

  • Exhaled nitric oxide: Nitric oxide is produced by cells in the airway in response to inflammatory markers. People with airway inflammation diseases like asthma and chronic obstructive pulmonary disorder exhale a higher-than-normal amount of nitric oxide, making it a useful biomarker for airway inflammation.[2][3][4]

  • 9-alpha, 11-beta PGF2: This is a metabolite of prostaglandin PGD2, a major inflammatory chemical released by mast cells upon activation. Both PGD2 and 9-alpha, 11-beta PGF2 contract smooth muscle. This effect, along with others, contribute to many of the symptoms of asthma.[5]

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Markers of airway inflammation.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d - - See study

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Click here to see all 5 references.