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Lower Esophageal Pressure

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Summary of Lower Esophageal Pressure

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Lower Esophageal Pressure

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect lower esophageal pressure
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Melatonin Notable - See study
Has been noted to increase LES pressure, which is thought to underlie symptoms reduction in GERD
grade-c Ginger Minor - See study
A decrease in LES pressure (not necessarily a good thing, especially for acid reflux) has been noted with ginger ingestion

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.