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Liver Damage

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Summary of Liver Damage

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Liver Damage


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver damage
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Trimethylglycine Minor - See all 3 studies
Preliminary evidence showed a large decrease in fibrotic area and inflammation in the livers of persons with NAFLD given high dose (20g) betaine, but the best evidence failed to find a significant influence. An interaction is apparent, but the exact role is not known as this time.
grade-c Cordyceps - - See study
grade-c S-Adenosyl Methionine - - See study
Supplemental SAMe in a study of persons with liver damage failed to confer rehabilitative effects
grade-d Vitamin E Minor - See study
In those with inflammatory liver damage, supplementation of vitamin E appears to be capable of reducing damage over a long period of time.

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.