Liver Damage Research Analysis

Summary of Liver Damage

Scientific Information on Liver Damage

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver damage

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Trimethylglycine	Minor	- See all 3 studies	Preliminary evidence showed a large decrease in fibrotic area and inflammation in the livers of persons with NAFLD given high dose (20g) betaine, but the best evidence failed to find a significant influence. An interaction is apparent, but the exact role is not known as this time.
Cordyceps	-	- See study
S-Adenosyl Methionine	-	- See study	Supplemental SAMe in a study of persons with liver damage failed to confer rehabilitative effects
Vitamin E	Minor	- See study	In those with inflammatory liver damage, supplementation of vitamin E appears to be capable of reducing damage over a long period of time.

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.