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Lipid Peroxidation

A form of oxidation that influences lipids. In the body, it tends to reflect damage to cell membranes and is assessed by biomarkers thought to represent lipid peroxidation (MDA and TBARS).

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Apr 20, 2013
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect lipid peroxidation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 4 studies
Appears to reduce biomarkers of lipid peroxidation. CoQ10 tends to be a reference drug for lipid peroxidation, and although it is more potent than other nutraceuticals it is not astounding.
grade-b Notable Very High See all 3 studies
Although there is no reference drug to compare the effects of Spirulina against, the decrease in lipid peroxidation as assessed by serum MDA is quite notable and is likely stronger than other supplements. A comparative study would be needed
grade-b
Minor
- See all 5 studies
While minor, increases in lipid peroxidation have been noted in nondiabetic controls while decreases have occurred in those with a high baseline HbA1c. A possible modulatory effect exists.

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

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