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Lipid Peroxidation

A form of oxidation that influences lipids. In the body, it tends to reflect damage to cell membranes and is assessed by biomarkers thought to represent lipid peroxidation (MDA and TBARS).

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect lipid peroxidation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Coenzyme Q10 Notable Very High See all 4 studies
Appears to reduce biomarkers of lipid peroxidation. CoQ10 tends to be a reference drug for lipid peroxidation, and although it is more potent than other nutraceuticals it is not astounding.
grade-b Spirulina Notable Very High See all 3 studies
Although there is no reference drug to compare the effects of Spirulina against, the decrease in lipid peroxidation as assessed by serum MDA is quite notable and is likely stronger than other supplements. A comparative study would be needed
grade-b Chromium
- See all 5 studies
While minor, increases in lipid peroxidation have been noted in nondiabetic controls while decreases have occurred in those with a high baseline HbA1c. A possible modulatory effect exists.
grade-b Creatine  
grade-b Curcumin  
grade-b Fish Oil  
grade-b L-Carnitine  
grade-b Vitamin C  
grade-b Vitamin E  
grade-b Zinc  
grade-b Astaxanthin  
grade-c Alpha-Lipoic Acid  
grade-c Cissus quadrangularis  
grade-c Cocoa Extract  
grade-c Garlic  
grade-c Kaempferia parviflora  
grade-c Licorice  
grade-c Melatonin  
grade-c Methylsulfonylmethane  
grade-c Olive leaf extract  
grade-c Rooibos  
grade-c Shilajit  
grade-c Alanylglutamine  
grade-c Citrulline  
grade-c Eleutherococcus senticosus  
grade-c Ganoderma lucidum  
grade-c Glutathione  
grade-c Red Clover Extract  
grade-c Rhodiola Rosea  
grade-c Stinging Nettle  
grade-c Trimethylglycine  
grade-d Aronia melanocarpa  
grade-d Ginger  
grade-d Blueberry  
grade-d Eclipta alba  
grade-d Green Tea Catechins  
grade-d Hibiscus sabdariffa  
grade-d Melissa officinalis  
grade-d Punicalagins  
grade-d Pyrroloquinoline quinone  
grade-d Rubus coreanus  
grade-d Stephania tetrandra  
grade-d Yerba mate  
grade-d Krill Oil  
grade-d Mangifera indica  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.