Quick Navigation

Leptin

Leptin is a well-known 'adipokine' (signalling molecule made in body fat) that acts as a nutrient sensor, and increases metabolic rate during periods of overfeeding; its secretion is sensitive to carbohydrate ingestion, and its elevation during dieting desired.

Our evidence-based analysis on leptin features 5 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Easily stay on top of nutrition research

Become an Examine.com member to get access to the latest research. 150+ studies summarized across 25 different categories every month.

Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes.

Already a member? Click here to log in.

Make informed decisions about your health

Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix looks at human studies to tell you what supplements affect Leptin.

Full details on all Leptin supplements are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 3 studies
Mixed influences on leptin, but melatonin may be able to increase leptin levels following acute administration
grade-c Notable - See study
An increase in circulating leptin has been noted with supplementation of pharmacological doses of niacin in subjects with metabolic syndrome.
grade-c Minor - See study
An increase in leptin has once been noted with usage of cannabis.

Become an Examine member — free to try for 14 days — to view this information.

You can currently view 3 supplements as a non-member - becoming a member will give you access to 16 total supplements on leptin.

Already a member? Log in now to access.

grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  

Stay on top of the latest research

Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. Information tailored to you, updated every month.

Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com.


Frequently Asked Questions and Articles on Leptin

Is sugar more filling than HFCS?
Click here to see all 5 references.