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Leptin

Leptin is a well-known 'adipokine' (signalling molecule made in body fat) that acts as a nutrient sensor, and increases metabolic rate during periods of overfeeding; its secretion is sensitive to carbohydrate ingestion, and its elevation during dieting desired.

Our evidence-based analysis on leptin features 5 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect leptin.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 3 studies
Mixed influences on leptin, but melatonin may be able to increase leptin levels following acute administration
grade-c Notable - See study
An increase in circulating leptin has been noted with supplementation of pharmacological doses of niacin in subjects with metabolic syndrome.
grade-c Minor - See study
May decrease leptin, but is confounded with weight loss

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By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.

Frequently Asked Questions and Articles on Leptin

Is sugar more filling than HFCS?
Click here to see all 5 references.